Differential Regulation of Enteric and Systemic Salmonellosis by slyA |
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| Authors: | Patricia R. Watson Sue M. Paulin A. Patricia Bland Stephen J. Libby Philip W. Jones Tim S. Wallis |
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| Affiliation: | Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. |
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| Abstract: | Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions in intestinal invasion and enteropathogenic responses in bovine ligated ileal loops. slyA appears to regulate virulence genes involved in systemic, but not enteric, salmonellosis. |
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