| 醋酸地塞米松对替硝唑大鼠体内药动学的影响 |
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| 引用本文： | 郭涛,常馨予,刘丛丛,左金梁,颜鸣,夏东亚. 醋酸地塞米松对替硝唑大鼠体内药动学的影响[J]. 中国药师, 2010, 13(8): 1090-1092 |
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| 作者姓名： | 郭涛 常馨予 刘丛丛 左金梁 颜鸣 夏东亚 |
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| 作者单位： | [1]沈阳市军区总医院药剂科,沈阳110016 [2]沈阳药科大学药学院,沈阳110016 |
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| 摘 要： | 目的：探讨醋酸地塞米松对替硝唑大鼠体内药动学的影响。方法：大鼠随机分为两组，每组5只，一组灌胃给予替硝唑，另一组灌胃给予醋酸地塞米松，连续5d，于第6天合并给药替硝唑与醋酸地塞米松，分别测定两组大鼠血浆中替硝唑的浓度，用DAS软件程拟合药动学参数。结果：单独给予替硝唑组和联合给药组的替硝唑的主要药动学参数：Cmax分别为（27．08±2．98）和（23．69±3．45）mg·L^-1,t1／2：（2．16±0．76）h和（1．95±0．31）h，AUC0-24h（138．04±5．84）和（119．90±11．46）mg·h·L^-1。两组间AUC及CL／F的差异有统计学意义（P〈0．05）。结论：醋酸地塞米松对替硝唑大鼠体内药动学过程影响较小。
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| 关 键 词： | 替硝唑 醋酸地塞米松 药物动力学 药物相互作用 |
Effect of Dexamethasone Acetate on the Pharmacokinetic of Tinidazole in Rats |
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| Guo Tao,Chang Xinyu,Liu Congcong,Zuo Jinliang,Yan Ming,Xia Dongya. Effect of Dexamethasone Acetate on the Pharmacokinetic of Tinidazole in Rats[J]. China Pharmacist, 2010, 13(8): 1090-1092 |
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| Authors: | Guo Tao Chang Xinyu Liu Congcong Zuo Jinliang Yan Ming Xia Dongya |
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| Affiliation: | 1. Dept. of pharmacy, General Hospital of Shenyang Military Region, Shenyang 110016, China 2. School of pharmacy, Shenyang Pharmaceutical University) |
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| Abstract: | Objective： To study the effect of dexamethasone acetate on the phal-macokinetic of tinidazole in rats. Method ： Ten rats were randomly divided into two equal groups ： A and B. Rats of group A were given tinidazole. Rats of group B were given dexamethasone acetate for five days, and tinidazole was given at the sixth day with the dexamethasone acetate. Blood samples were taken from the animals for the determination of the plasma concentration of tinidazole by HPLC. The pharmacokinetics parameters were calculated by DAS software. Result： The main pharmacokinetics parameters of group A were as follows： Cmax were （27.08 ± 2. 98） mg·L^-1 ,t1/2 were （2. 16 ± 0.76） h,AUC0-24 h were （ 138.04 ± 5.84 ） mg·h^-1·L^- 1. The main pharmacokinetics parameters of group B were as follows ： Cmax were （ 23.69 ±3.45 ） mg. L^-1 , t 1/2 were （ 1.95 ±0. 31 ） h, A UC0-24 h were （ 119. 90 ± 11.46 ） mg. h^- 1·L^ - 1. The results showed that the main pharmacokinetic parameters of tinidazole have significant differences between two groups. Conclusion： Dexamethasone acetate has little effect on the pharmacokinetic of tinidazole in rats. |
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| Keywords: | Tinidazole Dexamethasone acetate Pharmacokinetics Interaction |
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