| 术前血清甲状腺球蛋白检测对甲状腺乳头状癌颈部淋巴结转移的预测价值分析 |
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| 引用本文： | 王依莹,孔伟,刘庆华,邢浩,尹峰燕,刘新悦,何倩,邢薇佳. 术前血清甲状腺球蛋白检测对甲状腺乳头状癌颈部淋巴结转移的预测价值分析[J]. 实用肿瘤学杂志, 2023, 37(1): 52-57. DOI: 10.11904/j.issn.1002-3070.2023.01.009 |
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| 作者姓名： | 王依莹 孔伟 刘庆华 邢浩 尹峰燕 刘新悦 何倩 邢薇佳 |
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| 作者单位： | 1.山东第一医科大学公共卫生与健康管理学院(济南 250000); 2.山东第一医科大学第二附属医院甲状腺外科; 3.山东第一医科大学第二附属医院检验医学科; 4.泰安市中心医院甲状腺外科 |
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| 基金项目： | 山东省医药卫生科技发展计划项目(编号:202012050653) |
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| 摘 要： | 目的 探讨术前血清甲状腺球蛋白(Preoperative serum thyroglobulin,PS-Tg)与甲状腺乳头状癌(Papillary carcinoma of thyroid,PTC)淋巴结转移(Lymph node metastasis,LNM)的关系。方法 本研究纳入2021年10月—2022年10月行甲状腺切除术并经术后病理证实的PTC患者,并收集其临床及病理资料283份。单因素、多因素logistic回归分析PS-Tg与PTC LNM的关系,绘制列线图将两者关系量化,通过ROC曲线确定最佳截断值。结果 PTC合并LNM组PS-Tg水平高于单纯PTC组(P＜0.05),单因素与多因素logistic回归分析发现PS-Tg水平升高可能是PTC发生LNM的独立危险因素,且PS-Tg水平升高可解释约15%的PTC LNM风险。结论 PS-Tg水平升高可能是PTC患者颈部LNM的危险因素,对术前LNM诊断有一定的预测价值。
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| 关 键 词： | 甲状腺乳头状癌 淋巴结转移 术前血清甲状腺球蛋白 |
| 收稿时间： | 2022-11-25 |
Analysis for predictive value of preoperative serum thyroglobulin detection in cervical lymph node metastasis of thyroid papillary carcinoma |
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| WANG Yiying,KONG Wei,LIU Qinghua,XING Hao,YIN Fengyan,LIU Xinyue,HE Qian,XING Weijia. Analysis for predictive value of preoperative serum thyroglobulin detection in cervical lymph node metastasis of thyroid papillary carcinoma[J]. Journal of Practical Oncology, 2023, 37(1): 52-57. DOI: 10.11904/j.issn.1002-3070.2023.01.009 |
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| Authors: | WANG Yiying KONG Wei LIU Qinghua XING Hao YIN Fengyan LIU Xinyue HE Qian XING Weijia |
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| Affiliation: | 1. School of Public Health,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250000,China; 2. Department of Thyroid Surgery,The Second Affiliated Hospital of Shandong First Medical University; 3. Department of Clinical Laboratory,The Second Affiliated Hospital of Shandong First Medical University; 4. Department of Thyroid Surgery,Taian Central Hospital |
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| Abstract: | Objective The Objective of this study was to investigate the relationship between preoperative serum thyroglobulin(PS-Tg)and lymph node metastasis(LNM)in papillary thyroid carcinoma(PTC). Methods This study included 283 clinical and pathological data of PTC patients who underwent thyroidectomy from October 2021 to September 2022 and were confirmed by postoperative pathology.The relationship between PS-Tg and PTC LNM was analyzed by univariable and multivariable logistic regression,the nomogram was used to quantify the relationship between them,and the optimal cut-off value was determined by receiver operating characteristic(ROC)curves. Results The level of PS-Tg in the PTC combined with LNM group was higher than that in the pure PTC group(P＜0.05).Univariable and multivariable logistic regression analyses showed that elevated PS-Tg level might be an independent risk factor for LNM of PTC,and the increase of PS-Tg level could explain approximately 15% of the risk of LNM in PTC. Conclusion Elevated PS-Tg level may be a risk factor for cervical LNM in PTC patients,and it has a certain predictive value for preoperative LNM diagnosis. |
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| Keywords: | Papillary thyroid carcinoma Lymph node metastasis Preoperative serum thyroglobulin |
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