| 脂蛋白相关磷脂酶A2与早发冠心病的相关性及其临床意义 |
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| 引用本文： | 谷阳,刘万波,陈雨,徐海,卢周舟,张喜文. 脂蛋白相关磷脂酶A2与早发冠心病的相关性及其临床意义[J]. 心脏杂志, 2019, 30(1): 28-30,33. DOI: 10.12125/j.chj.201806037 |
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| 作者姓名： | 谷阳 刘万波 陈雨 徐海 卢周舟 张喜文 |
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| 作者单位： | 2.Clinical Laboratory, Affiliated Huaian No.1 Peopole’s Hospital of Nanjing Medical University, huaian 223300, Jiangsu, China |
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| 摘 要： | 目的研究早发冠心病患者的危险因素,探讨脂蛋白相关磷脂酶(Lp-PL) A2水平与早发冠心病的相关性及临床意义。方法选取因胸痛住院并行冠状动脉造影,确诊为早发冠心病的患者63例。选取同期行冠脉造影,血管管腔狭窄<50%的患者30例作为对照组。分析(Lp-PL) A2水平与GRACE风险评分和Gensini积分的相关性。Logistic回归分析早发冠心病的危险因素。结果①早发冠心病组的脂蛋白相关磷脂酶A2水平显著高于对照组(P <0. 05)。②早发冠心病患者的脂蛋白相关磷脂酶A2水平与Gensini积分、GRACE风险评分显著相关(r=0. 368,P <0. 05; r=0. 402,P <0. 05)。③Logistic回归结果显示(Lp-PL) A2水平是早发冠心病的独立相关因素(P <0. 05)。结论 (Lp-PL) A2水平是早发冠心病的独立相关因素,与冠状动脉病变严重程度呈正相关,对评估早发冠心病的风险具有重要的临床应用价值。
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| 关 键 词： | 早发冠心病 危险因素 脂蛋白相关磷脂酶A2 |
| 收稿时间： | 2018-06-19 |
The correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance |
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| GU Yang,LIU Wan-bo,CHEN Yu,XU Hai,LU Zhou-zhou,ZHANG Xi-wen. The correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance[J]. Chinese Heart Journal, 2019, 30(1): 28-30,33. DOI: 10.12125/j.chj.201806037 |
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| Authors: | GU Yang LIU Wan-bo CHEN Yu XU Hai LU Zhou-zhou ZHANG Xi-wen |
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| Affiliation: | 2.Clinical Laboratory, Affiliated Huaian No.1 Peopole’s Hospital of Nanjing Medical University, huaian 223300, Jiangsu, China |
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| Abstract: | AIM To study risk factors of patients with premature coronary heart disease and to investigate the correlation between lipoprotein-associated phospholipase A2 and premature coronary heart disease and its clinical significance. METHODS 93 patients underwent coronary angiography were divided into premature coronary heart disease group (n=63) and a control group (coronary artery stenosis <50%, n=30). The Lp-PLA2 levels were investigated between the two groups and the relationship of Lp-PLA2 with risk of patients was studied. RESULTS Lp-PLA2 levels were significantly higher in premature coronary heart disease group than in the control group(P<0.05). Lp-PLA2 had a significant correlation with Gensini score (r=0.368,P<0.05) and GRACE risk score (r=0.402,P<0.05). Multivariate logistic regression analysis showed that Lp-PLA2 was independently associated with premature coronary heart disease (P<0.05). CONCLUSION Lp-PLA2 is independently associated with premature coronary heart disease and positively related with the severity of coronary artery and prognosis. Thus Lp-PLA2 can be used as a predictor of risk assessment in premature coronary heart disease patients. |
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| Keywords: | premature coronary heart disease risk factors lipoprotein-associated phospholipase A2 |
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