Association of thrombocytopenia with outcome following adult living donor liver transplantation |
| |
| Authors: | Viniyendra Pamecha Shyam Sunder Mahansaria Senthil Kumar Kishore Gurumoorthy Subramanya Bharathy Shridhar Vasantrao Sasturkar Piyush Kumar Sinha Niteen Kumar Vaibhaw Kumar |
| |
| Affiliation: | Department of Liver Transplantation and Hepato Pancreatico Biliary Surgery, Institute of Liver & Biliary Sciences, New Delhi, India |
| |
| Abstract: | This study aimed to evaluate the association of postoperative thrombocytopenia with outcome following adult living donor liver transplantation (LDLT) for end‐stage liver disease (ESLD). It was a prospective study of 120 consecutive adult LDLT from September 2012 to May 2015. Preoperative platelet counts (PLTs) and postoperative PLTs were recorded at regular intervals till 3 months after LDLT. Univariate and multivariate analyses were performed. The median pretransplant PLT was 61 × 109/l. The lowest median PLT after LDLT was observed on POD 3. Patients were stratified into low platelet group (n = 83) with PLT <30 × 109/l and high platelet group (n = 37) with PLT ≥30 × 109/l. Patients with PLT <30 × 109/l had statistically significant higher grade III/IV complication (P = 0.001), early graft dysfunction (P = 0.01), sepsis (P = 0.001), and prolonged ascites drainage (P = 0.002). On multivariate analysis, PLT<30 × 109/l was identified as an independent risk factor for grade III/IV complications (P = 0.005). Overall, patients survival was significantly different between two groups (P = 0.04), but this predictive value was lost in patients who survived more than 90 days (P = 0.37). Postoperative PLT of <30 × 109/l was a strong predictor of major postoperative complications and is associated with early graft dysfunction, prolonged ascites drainage, and sepsis. The perioperative mortality rate was high in the thrombocytopenia group. |
| |
| Keywords: | end‐stage liver disease living donor liver transplantation platelet counts |
|
|
