Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice |
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| Authors: | Wilkinson K A Martin T D Reba S M Aung H Redline R W Boom W H Toossi Z Fulton S A |
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| Affiliation: | Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984, USA. |
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| Abstract: | Latency-associated peptide of transforming growth factor beta (TGF-beta) (LAP) was used to determine whether in vivo modulation of TGF-beta bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-beta. |
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