| 儿童隐性脊柱裂对单症状性夜遗尿治疗及复发的影响 |
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| 引用本文： | 谭俊杰,于力. 儿童隐性脊柱裂对单症状性夜遗尿治疗及复发的影响[J]. 临床儿科杂志, 2021, 39(2): 113-116. DOI: 10.3969/j.issn.1000-3606.2021.02.008 |
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| 作者姓名： | 谭俊杰 于力 |
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| 作者单位： | 广东省清远市妇幼保健院儿科 广东清远 511510;广东省广州市第一人民医院儿科 广东广州 510180 |
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| 摘 要： | 目的 探讨隐性脊柱裂对儿童单症状性夜遗尿治疗及其复发的影响.方法 选择2018年9月至2019年9月单症状性夜遗尿患儿186例,从中筛选出伴隐性脊柱裂患儿98例,随机分为对照组(醋酸去氨加压素组)41例和观察组(醋酸去氨加压素联合奥昔布宁组)57例,所有患儿均给予干床训练.观察患儿治疗6个月和停药3个月的治疗效果、复发...
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| 关 键 词： | 隐性脊柱裂 单症状性夜遗尿 治疗 复发 |
Impact of spina bifida occulta in children on recurrence and treatment of monosymptomatic nocturnal enuresis |
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| TAN Junjie,YU Li. Impact of spina bifida occulta in children on recurrence and treatment of monosymptomatic nocturnal enuresis[J]. The Journal of Clinical Pediatrics, 2021, 39(2): 113-116. DOI: 10.3969/j.issn.1000-3606.2021.02.008 |
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| Authors: | TAN Junjie YU Li |
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| Affiliation: | 1.Maternal and Child Health Hospital Of Qingyuan City, Qingyuan 511510 , Guangdong, China； 2.Department of Pediatrics, Guangzhou First People's Hospital, Guangzhou 510180, Guangdong, China |
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| Abstract: | Objective To investigate the effect of spina bifida occulta on the recurrence of monosymptomatic nocturnal enuresis in children and its treatment.Methods A total of 186 children with monosymptomatic nocturnal enuresis from September 2018 to September 2019 were selected,of them 98 children with spina bifida occulta were selected and randomly grouped into a control group(desmopressin group,n=41)and an observation group(desmopressin combined with oxybutynin group,n=57),and all children were given dry bed training.The treatment effect and adverse effects of the children were observed after 6 months of treatment and 3 months of drug withdrawal.Results After 6 months of treatment,the control group had a complete effect rate of 61.0%and a total effective rate of 68.3%;the observation group had a complete effect rate of 80.7%and a total effective rate of 91.2%.The differences in the complete effect rate(χ2=4.65,P=0.031)and the total effective rate(χ2=8.37,P=0.004)between the two groups were statistically significant.Three months after discontinuation of the drug,11(26.8%)of the 41 control children relapsed and 6(10.5%)of the 57 observed children relapsed,with a statistically significant difference between the two groups(χ2=4.42,P=0.036).Conclusion Spina bifida occulta was found to be highly prevalent in children with monosymptomatic nocturnal enuresis and to be prone to recurrence of enuresis during treatment.The combination of desmopressin with oxybutynin for the treatment was effective on increasing the complete response rate and efficiency,decreasing the recurrence rate,and on providing good compliance and safety. |
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| Keywords: | spina bifida occulta monosymptomatic nocturnal enuresis treatment relapse |
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