| 冠状动脉钙化积分与冠状动脉疾病及全因性死亡相关性的Meta分析 |
| |
| 引用本文： | 毕月,李拥军,王萌萌. 冠状动脉钙化积分与冠状动脉疾病及全因性死亡相关性的Meta分析[J]. 临床荟萃, 2021, 36(4): 293-302. DOI: 10.3969/j.issn.1004-583X.2021.04.001 |
| |
| 作者姓名： | 毕月 李拥军 王萌萌 |
| |
| 作者单位： | 河北医科大学 研究生院,河北 石家庄 050017;河北医科大学第二医院 心内四科,河北 石家庄 050000 |
| |
| 基金项目： | 国家自然科学基金面上项目——RhoA/ROCK信号通路介导的自噬障碍在2型糖尿病心肌损伤中的作用(81570345) |
| |
| 摘 要： | 目的系统评价冠状动脉钙化积分(CACS)与冠状动脉疾病(CAD)及全因死亡事件相关性。方法计算机检索Pubmed、The Cochrane Library、EMbase、CKNI、WanFang Data数据库,搜集CACS与CAD及全因性死亡(All-cause mortality)相关性的队列研究,检索时限从建库至2020年6月。由2名资料员提取文献并进行评价纳入研究的偏倚风险后,采用Stata 14.0软件进行Meta分析。结果纳入11个队列研究,包括59143例被研究者。Meta结果显示:与CACS<10相比,CACS≤100组[HR=2.46,95%CI(1.77,3.41),P=0.000,I^(2)=55.5%]、100
|
| 关 键 词： | 冠状动脉疾病 冠状动脉钙化积分 全因死亡事件 Meta分析 |
| 收稿时间： | 2020-08-19 |
Meta analysis of correlation between coronary artery calcification score and coronary artery disease and all-cause mortality |
| |
| Bi Yue,Li Yongjun,Wang Mengmeng. Meta analysis of correlation between coronary artery calcification score and coronary artery disease and all-cause mortality[J]. Clinical Focus, 2021, 36(4): 293-302. DOI: 10.3969/j.issn.1004-583X.2021.04.001 |
| |
| Authors: | Bi Yue Li Yongjun Wang Mengmeng |
| |
| Affiliation: | 1. Graduate Academy of Hebei Medical University,Shijiazhuang,Hebei 050017,China2. Fourth Department of Vasculocardiology,Second Hospital of Hebei Medical University,Shijiazhuang,Hebei 050000,China |
| |
| Abstract: | Objective To systematically review the correlations among coronary artery calcification score(CACS), coronary artery disease and all-cause mortality. Methods The databases of Pubmed, The Cochrane Library, EMbase, CKNI and WanFang Data were electronically searched to collect cohort studies on the correlations between CACS, CAD and all-cause mortality from the inception of databases to June 2020. Meta analysis was performed with Stata 14.0 software when two data clerks independently screened literatures, they extracted data and assessed risk of bias of included studies. Results A total of 11 cohort studies were included, including 59 143 cases. The Meta results showed that CACS≤100 group [HR=2.46,95%CI(1.77,3.41),P=0.000,I2=55.5%],100HR=3.62,95%CI(2.24,5.83),P=0.000,I2=42.2%] and CACS>400 group [HR=5.09,95%CI(2.02,12.84),P=0.001,I2=70.7%] are more likely to occur CAD and all-cause deaths compared to CACS<10 group. Conclusion There is a higher risk of coronary artery disease and all-cause mortality for patients with CAC. |
| |
| Keywords: | coronary artery disease coronary artery calcification score(CACS) all-cause mortality meta analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《临床荟萃》浏览原始摘要信息 |
|
点击此处可从《临床荟萃》下载全文 |
|
