| 组织工程化前交叉韧带在运动损伤修复中应用 |
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| 引用本文： | 施海平. 组织工程化前交叉韧带在运动损伤修复中应用[J]. 中国组织工程研究, 2011, 15(46): 8722-8725. DOI: 10.3969/j.issn.1673-8225.2011.46.041 |
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| 作者姓名： | 施海平 |
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| 作者单位： | 上海工程技术大学体育部,上海市 201620 |
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| 摘 要： | 背景：运动员前交叉韧带的损伤极难彻底恢复,降低运动寿命。目的：总结组织工程化前交叉韧带在运动损伤修复中的研究现状和最新进展。方法：采用计算机检索维普数据库和PubMed数据库1994-01/2010-12相关文章,纳入28篇与运动性前交叉韧带损伤及组织工程韧带相关的文章,重点对组织工程前交叉韧带重建的研究进展、前交叉韧带种子细胞的来源、细胞因子在前交叉韧带重建中的应用及组织工程前交叉韧带附丽的基础研究4个方面进行探讨。结果与结论：运动中前交叉韧带损伤后自体愈合能力极差,对于运动员伤后痊愈造成极大困难。组织工程前交叉韧带近些年来飞速发展,具有良好的应用和发展前景。但在实际应用过程中,组织工程化种子细胞的选择、支架材料的构建和组织工程前交叉韧带附丽的基础研究三者有机相互融合,并合理应用生长因子,才能在临床上起到最佳治疗效果,最终达到修复和重建前交叉韧带的目的。
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| 关 键 词： | 前交叉韧带 组织工程 修复 细胞因子 种子细胞 附丽 |
| 收稿时间： | 2011-05-15 |
Application of tissue-engineered anterior cruciate ligament in repair of exercise injury |
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| Shi Hai-ping. Application of tissue-engineered anterior cruciate ligament in repair of exercise injury[J]. Chinese Journal of Tissue Engineering Research, 2011, 15(46): 8722-8725. DOI: 10.3969/j.issn.1673-8225.2011.46.041 |
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| Authors: | Shi Hai-ping |
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| Affiliation: | Department of Physical Education, Shanghai University of Engineering Science, Shanghai 201620, China |
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| Abstract: | BACKGROUND:Anterior cruciate ligament injury is extremely difficult for athletes to fully recover, and can shorten the exercise span. OBJECTIVE:To summarize the recent research progress on the application of tissue-engineered anterior cruciate ligament in repair of exercise injury.METHODS:An online search of VIP database and PubMed database was performed for relevant articles published between January 1994 and December 2010. A total of 28 articles on sports-related anterior cruciate ligament injury and tissue-engineered ligament were retrieved. The discussion was mainly focused on the recent development of tissue-engineered anterior cruciate ligament reconstruction, the sources of anterior cruciate ligament seed cells, the application of cytokine in reconstruction of anterior cruciate ligament and the basic research on tissue-engineered anterior cruciate ligament.RESULTS AND CONCLUSION:Autohealing ability of sports-related anterior cruciate ligament is extremely poor, so it is extremely difficult for athletes to recover. In recent years, research on tissue-engineered anterior cruciate ligament has made rapid progress with prospect and extensive application. But with regard to application, the optimal clinical outcomes of anterior cruciate ligament repair and reconstruction can only be achieved by organically blending the selection of tissue-engineered seed cells, the construction of scaffold materials with the basic research on tissue-engineered anterior cruciate ligament, as well as using growth factor properly. |
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