| 钛质外科网和纳米仿生骨在颈椎前路减压融合中的应用 |
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| 引用本文： | 杨朝垒,王利民,刘屹林,谭宏宇,王卫东. 钛质外科网和纳米仿生骨在颈椎前路减压融合中的应用[J]. 中国组织工程研究, 2011, 15(3): 413-416. DOI: 10.3969/j.issn.1673-8225.2011.03.008 |
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| 作者姓名： | 杨朝垒 王利民 刘屹林 谭宏宇 王卫东 |
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| 作者单位： | 郑州大学第一附属医院骨科,河南省郑州市 450052 |
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| 基金项目： | 国家科技支撑计划课题----活性纳米复合生物材料制品手术示范与临床应用(2007BAE13B00 )。 |
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| 摘 要： | 背景：纳米羟基磷灰石/聚酰胺作为新型植骨材料,应用于颈椎前路减压融合中,不仅可以减少患者取骨带来的并发症,而且具有稳定的植骨融合率。目的：比较钛网和纳米羟基磷灰石/聚酰胺应用于颈椎前路减压融合治疗脊髓型颈椎病的临床效果。方法：对确诊的48例脊髓型颈椎病患者行颈前路椎体次全切减压融合钛板内固定。其中26例行钛网植骨,22例行纳米羟基磷灰石/聚酰胺仿生骨植骨,采用JOA评分法评价神经功能的恢复,测量cobb角评价融合节段曲度。结果与结论：48例患者均获得随访,随访时间6~14个月。置入后3个月JOA评分较置入前明显改善,两组对比JOA评分差异无显著性意义;置入后3,6个月钛网组及仿生骨组融合节段cobb角相对于置入后即刻变化差异有显著性意义,两组对比差异无显著性意义;置入后3个月钛网组2例患者出现钛网沉降,融合节段椎间高度丢失。结果表明纳米羟基磷灰石/聚酰胺仿生骨作为颈椎前路融合植骨材料,融合率高,可以有效保持颈椎生理曲度及椎间高度,长期效果有待进一步观察。
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| 关 键 词： | 颈椎病 钛质外科网 纳米羟基磷灰石/聚酰胺 前路植骨融合 生物相容性 |
| 收稿时间： | 2010-08-14 |
A comparison between titanium surgical mesh and bionic nano-bone in anterior cervical decompression and fusion |
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| Yang Chao-lei,Wang Li-min,Liu Yi-lin,Tan Hong-yu,Wang Wei-dong. A comparison between titanium surgical mesh and bionic nano-bone in anterior cervical decompression and fusion[J]. Chinese Journal of Tissue Engineering Research, 2011, 15(3): 413-416. DOI: 10.3969/j.issn.1673-8225.2011.03.008 |
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| Authors: | Yang Chao-lei Wang Li-min Liu Yi-lin Tan Hong-yu Wang Wei-dong |
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| Affiliation: | Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China |
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| Abstract: | BACKGROUND:Nano-hydroxyapatite/polyamide as a new bone graft material is used in anterior cervical decompression and fusion, it not only reduces the complications after bone removal, and exhibits a stable graft fusion rate.OBJECTIVE: To study clinical effect of titanium surgical mesh versus nano-hydroxyapatite and polyamide composite (n-HA/PA66) in anterior cervical decompression and fusion for treatment of cervical sondylotic myelopathy. METHODS:A total of 48 cases of cervical spondylotic myelopathy were treated with anterior cervical subtotal corpectomy and fusion, titanium locking plates fixation, 26 with titanium surgical mesh, 22 with n-HA/PA66. The JOA grading system was done to evaluate neural functional restoration, and Cobb’s angle was measured to evaluate the change of cervical curvature. RESULTS AND CONCLUSION:All 48 patients were operated successfully and followed up for 6-14 months. The JOA grading scores were greatly improved in both groups at 3 months postoperation compared with before operation, without significant differences between two groups; at 3 and 6 months postoperation, the Cobb’s angle of all patients had significant differences compared with immediately after operation, without significant differences between two groups; 2 cases were evidenced subsidence of titanium surgical mesh and loss of vertebral height after three months of operation. N-HA/PA66 bionic bone as a graft of anterior cervical fusion has good fusion rate, and could effectively maintain the biological alignment and cervical intervertebral height. The long-term effects depend on further follow-up. |
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