| 新生儿携带MRSA和MSSA的现状及其耐药谱分析 |
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| 引用本文： | 王莹莹, 周鑫, 吴传安, 郑惠结, 郑浩渠, 姚振江. 新生儿携带MRSA和MSSA的现状及其耐药谱分析[J]. 中华疾病控制杂志, 2019, 23(10): 1297-1300. doi: 10.16462/j.cnki.zhjbkz.2019.10.027 |
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| 作者姓名： | 王莹莹 周鑫 吴传安 郑惠结 郑浩渠 姚振江 |
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| 作者单位： | 1.510310 广州, 广东药科大学公共卫生学院流行病与卫生统计学教研室;;2.518109 深圳, 深圳市龙华新区妇幼保健中心信息科 |
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| 基金项目： | 广东省科技计划项目2014A020213013广东药科大学“创新强校工程”资助项目2016 |
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| 摘 要： | 目的 了解新生儿耐甲氧西林金黄色葡萄球菌（methicillin-resistant staphylococcus aureus，MRSA）和甲氧西林敏感金黄色葡萄球菌（methicillin-sensitive staphylococcus aureus，MSSA）的携带现状及其耐药情况。 方法 采用横断面研究，于2015年8月-11月，对深圳市龙华区人民医院和观澜医院的1 834名新生儿进行棉拭子采样、菌株分离鉴定及药物敏感试验。 结果 新生儿金黄色葡萄球菌（staphylococcus aureus，SA）、MRSA、MSSA的携带率分别为3.27%（60/1 834）、0.82%（15/1 834）、2.45%（45/1 834）。MRSA与MSSA对青霉素、红霉素的耐药率较高，对利奈唑胺的耐药率均小于10%。MRSA对红霉素、莫西沙星、克林霉素的耐药率均高于MSSA（均有P < 0.05）；MRSA的多重耐药率高达80.00%，风险是MSSA的12.36倍。 结论 该地区新生儿SA尤其是MRSA多重耐药率较高，且MRSA耐药情况比MSSA更严重。
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| 关 键 词： | 新生儿 MRSA MSSA 携带现状 耐药谱 |
| 收稿时间： | 2019-04-01 |
| 修稿时间： | 2019-07-10 |
Carriage prevalence and drug resistance profile of MRSA and MSSA strains isolated from newborns |
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| WANG Ying-ying, ZHOU Xin, WU Chuan-an, ZHENG Hui-jie, ZHENG Hao-qu, YAO Zhen-jiang. Carriage prevalence and drug resistance profile of MRSA and MSSA strains isolated from newborns[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(10): 1297-1300. doi: 10.16462/j.cnki.zhjbkz.2019.10.027 |
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| Authors: | WANG Ying-ying ZHOU Xin WU Chuan-an ZHENG Hui-jie ZHENG Hao-qu YAO Zhen-jiang |
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| Affiliation: | 1. Faculty of Epidemiology and Health Statistics, School of public health, Guangdong pharmaceutical university, Guangzhou 510310, China;;2. Department of Information, Shenzhen Longhua New District Maternal and Child Health Center, Shenzhen 518109, China |
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| Abstract: | Objective To determine the carriage prevalence and antibiotics resistance profile of methicillin-resistant staphylococcus aureus(MRSA) and methicillin-sensitive staphylococcus aureus(MSSA) strains isolated from newborns. Methods A cross-sectional study was conducted in two hospitals in Shenzhen from August to November 2015. Cotton swab samples were collected from 1834 newborns. Staphylococcus aureus was identified by general laboratory tests, and antimicrobial-susceptibility profiles was tested. Results In total, 3.27% (60/1 834) Staphylococcus aureus (SA) strains were isolated, including 0.82% (15/1 834) MRSA and 2.45% (45/1 834) MSSA. Most MRSA and MSSA strains were resistant to penicillin and erythromycin but less than 10% strains resistant to linezolid. Drugs resistance rates of MRSA to erythromycin, moxifloxacin and clindamycin were all higher than that of MSSA (all P < 0.05). The multidrug-resistant risk of MRSA (80.00%) was 12.36 times higher than that of MSSA (24.44%). Conclusions Multidrug-resistant SA especially MRSA strains isolated from newborns had the higher prevalence, the drugs resistance rate of MRSA strains was more serious than that of MSSA. |
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| Keywords: | Newborns MRSA MSSA Carriage prevalence Antibiotics resistance profile |
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