| GNAS1 T393C基因多态性与实体瘤遗传易感性的Meta分析 |
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| 引用本文： | 程 林,孙凤军,夏培元. GNAS1 T393C基因多态性与实体瘤遗传易感性的Meta分析[J]. 现代肿瘤医学, 2019, 0(21): 3882-3886. DOI: 10.3969/j.issn.1672-4992.2019.21.035 |
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| 作者姓名： | 程 林 孙凤军 夏培元 |
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| 作者单位： | 陆军军医大学第一附属医院药学部，重庆 400038 |
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| 基金项目： | 重庆市社会事业与民生保障科技创新专项分课题（编号:cstc2016shms-ztcs 10004） |
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| 摘 要： | 目的:系统评价GNAS1 T393C基因多态性与实体瘤遗传易感性的关系。方法:检索《PubMed》、《Web of Science》、《Cochrane Library》、《Embase》、《中国期刊全文数据库》、《中国生物医学文献数据库》、《维普数据库》、《万方数据库》，收集研究GNAS1 T393C基因多态性与实体瘤遗传易感性文献，文献发表时间为自数据库建库以来至2018年8月。由两位评价员独立筛选文献、提取资料，采用stata 12.0统计软件进行Meta分析。结果:共纳入7项研究，包括1 313例实体瘤患者。Meta分析结果显示，携带GNAS1 T393C TT基因型和TC+CC基因型人群实体瘤的遗传易感性差异无统计学意义（P=0.292），携带GNAS1 T393C T等位和C等位基因人群实体瘤的遗传易感性差异无统计学意义（P=0.355）。亚组分析显示，携带GNAS1 T393C TT基因型和TC+CC基因型亚洲人和高加索人实体瘤的遗传易感性差异无统计学意义（P=0.245、P=0.521），携带GNAS1 T393C T等位和C等位基因亚洲人和高加索人实体瘤的遗传易感性差异无统计学意义（P=0.208、P=0.206）；携带GNAS1 T393C TT基因型和TC+CC基因型人群泌尿生殖系统肿瘤的遗传易感性差异无统计学意义（P=0.300），携带GNAS1 T393C T等位和C等位基因人群泌尿生殖系统肿瘤的遗传易感性差异无统计学意义（P=0.266）。结论:GNAS1 T393C基因多态性与实体瘤遗传易感性无明显相关性。
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| 关 键 词： | 实体瘤 GNAS1 T393C 基因多态性 遗传易感性 Meta分析 |
Relationship between GNAS1 T393C gene polymorphisms and genetic predisposition of solid tumors:A Meta-analysis |
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| Cheng Lin,Sun Fengjun,Xia Peiyuan. Relationship between GNAS1 T393C gene polymorphisms and genetic predisposition of solid tumors:A Meta-analysis[J]. Journal of Modern Oncology, 2019, 0(21): 3882-3886. DOI: 10.3969/j.issn.1672-4992.2019.21.035 |
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| Authors: | Cheng Lin Sun Fengjun Xia Peiyuan |
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| Affiliation: | Department of Pharmacy，the First Affiliated Hospital of Army Medical University，Chongqing 400038，China. |
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| Abstract: | Objective:To systematically evaluate the relationship between GNAS1 T393C gene polymorphisms and genetic predisposition of solid tumors.Methods:Databases including PubMed，Web of Science，Cochrance Library，Embase，Chineses Journals Full-text Database，China Biology Medicine disc，VIP Database，and Wanfang Database were searched to obtain the trails investigating relationship between GNAS1 T393C gene polymorphisms and genetic predisposition of solid tumors from the establishment of each database to August 2018.Two reviewers independently screened literature and extracted data，and evaluated the methodological quality of included studies.Then，Meta-analysis was performed using stata 12.0 software.Results:A total of 7 trials involving 1 313 patients with solid tumors were included.The results of Meta-analysis showed that，there was no statistically significant difference in genetic predisposition of solid tumors between patients with GNAS1 T393C TT genotype and TC+CC genotype (P=0.292)，and there was no statistically significant difference in genetic predisposition of solid tumors between patients with GNAS1 T393C T allele and C allele (P=0.355).Subgroup analysis showed that there was no statistically significant difference in genetic predisposition of solid tumors between Asian and Caucasian with GNAS1 T393C TT genotype and TC+CC genotype (P=0.245，P=0.521)，and there was no statistically significant difference in genetic predisposition of solid tumors between Asian and Caucasian with GNAS1 T393C T allele and C allele (P=0.208，P=0.206).There was no statistically significant difference in genetic predisposition of urogenital neoplasms between patients with GNAS1 T393C TT genotype and TC+CC genotype (P=0.300)，and there was no statistically significant difference in genetic predisposition of urogenital neoplasms between patients with GNAS1 T393C T allele and C allele (P=0.266).Conclusion:There was no obvious correlation between GNAS1 T393C gene polymorphisms and genetic predisposition of solid tumors. |
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| Keywords: | solid tumors GNAS1 T393C gene polymorphisms genetic predisposition Meta-analysis |
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