| 肿瘤患者人附红细胞体感染因素分析 |
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| 引用本文： | 周莲莲,李芳,李绵绵,陈小剑. 肿瘤患者人附红细胞体感染因素分析[J]. 中华全科医学, 2019, 17(7): 1105-1108. DOI: 10.16766/j.cnki.issn.1674-4152.000874 |
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| 作者姓名： | 周莲莲 李芳 李绵绵 陈小剑 |
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| 作者单位： | 温州医科大学附属第二医院临床检验中心, 浙江 温州 325027 |
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| 基金项目： | 浙江省医药卫生科技计划项目(2016KYB200)；温州市科技局基础性科研项目(Y20180797) |
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| 摘 要： | 目的 分析人附红细胞体在肿瘤患者中的流行情况并初步分析感染因素。 方法 2016年8月—2018年7月从就诊人群中随机抽样，获得肿瘤组106人和健康体检组114人，采集EDTA-K2抗凝全血，采用瑞氏染色法和吖啶橙荧光染色法对标本进行染色，以二者皆为阳性确定为人附红细胞体感染，并收集年龄、性别、血细胞计数、干预治疗情况等信息，运用χ2检验对阳性率进行差异性分析。 结果 肿瘤组和健康体检组人附红细胞体感染率分别为33.02%和11.40%，差异具有统计学意义(χ2=15.045，P<0.001)；肿瘤患者组人附红细胞体感染率在不同系统肿瘤、是否经过干预治疗、红细胞计数、血小板计数、各年龄分布、性别分布等因素中差异无统计学意义(均P>0.05)；在白细胞计数增加组中感染率出现了增高的趋势(χ2=2.885，P=0.089)，健康体检组中儿童与成人人附红细胞体感染率差异无统计学意义(χ2=0.492，P>0.05)。 结论 肿瘤患者和健康体检者均存在一定程度的人附红细胞体感染，但肿瘤患者比健康体检者更易感染人附红细胞体；肿瘤患者白细胞计数增加可能存在人附红细胞体感染的情况；肿瘤患者人附红细胞体的感染率与是否经过干预治疗、肿瘤系统类别、红细胞计数、血小板计数、年龄、性别等因素无明显相关；健康体检者人附红细胞体的感染率与年龄无关。
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| 关 键 词： | 人附红细胞体 附红细胞体病 肿瘤患者 流行病学 吖啶橙荧光染色 感染 |
| 收稿时间： | 2018-08-27 |
Eperythrozoon infection and related infection factors in patients with tumors |
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| Affiliation: | Department of Laboratory Medicine, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027,China |
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| Abstract: | Objective To investigate the epidemic status of Eperythrozoon infection and related infection factors in patients with tumors. Methods A total of 106 patients with cancer and 114 patients of healthy physical examination were recruited by random sampling method from August 2016 to July 2018. The EDTA-K2 anticoagulant whole blood were collected and stained by Wright staining and acridine orange fluorescence staining to determine the infection of Eperythrozoon. Both of them were positive for Eperythrozoon infection and all the relevant information (age, gender, whole blood count, treatment etc) was collected. Chi-square test were applied to analyze the difference of positive rates. Results The corresponding infection rates in the patients group and health control group were 33.02% and 11.40%, and there were significant statistical difference among them (χ2=15.045, P<0.001). There was no significant difference in the infection rate of Eperythrozoon in tumor patients in different systemic tumors, intervention treatment, erythrocyte blood count, platelet count, age distribution and gender distribution (all P>0.05). The trend of increased rates of infection in increased white blood cell count group was reflected (χ2=2.885, P=0.089). The infection rate of Eperythrozoon in healthy persons has no statistical significant difference between children and adults (χ2=0.492, P>0.05). Conclusion There was mild infection of Eperythrozoon in patients with tumor and healthy people, but the infection rate of patients with tumor was significantly higher than that of healthy people; The tumor patients with the increased WBC count maybe infected with human eperythrozoon; The infection rate of human erythrocyte in patients with tumors is not related to the factors of intervention treatment, tumor system, red blood count, platelet count, age, gender etc. The infection rate of human erythrocytes in healthy subjects was not related to age. |
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