| 2型糖尿病患者肥胖状态与肱踝脉搏波传导速度的相关性 |
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| 引用本文： | 黄哲, 许蓓蓓, 王小文, 姚珊珊, 曹桂莹, 李曼, 曹亚英, 田耀华, 吴瑶, 黄少平, 刘晓芬, 秦雪英, 唐迅, 李劲, 吴涛, 陈大方, 胡永华. 2型糖尿病患者肥胖状态与肱踝脉搏波传导速度的相关性[J]. 中华疾病控制杂志, 2019, 23(9): 1086-1091. doi: 10.16462/j.cnki.zhjbkz.2019.09.014 |
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| 作者姓名： | 黄哲 许蓓蓓 王小文 姚珊珊 曹桂莹 李曼 曹亚英 田耀华 吴瑶 黄少平 刘晓芬 秦雪英 唐迅 李劲 吴涛 陈大方 胡永华 |
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| 作者单位： | 1.100191 北京, 北京大学公共卫生学院流行病与卫生统计学系;;2.100191 北京, 北京大学医学信息学中心;;3.102401 北京, 北京市房山区疾病预防控制中心办公室;;4.102488 北京, 北京市房山区疾病预防控制中心慢性病防治科 |
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| 基金项目： | 国家自然科学基金81230066国家自然科学基金81473043国家自然科学基金81872695 |
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| 摘 要： | 目的 探讨2型糖尿病（type 2 diabetes，T2DM）患者全身性肥胖（overall obesity，OO）、中心性肥胖（abdominal obesity，AO）状态与肱踝脉搏波传导速度（brachial-ankle pulse wave velocity，baPWV）的关联。 方法 以北京某社区T2DM患者为研究对象，收集人口学资料、体格检查数据、血液生化指标及baPWV。采用多元线性回归分析各肥胖指标与baPWV的关联，采用Logistic回归模型探讨肥胖状态与baPWV异常（baPWV≥1700 cm/s）的关联。 结果 共纳入2 048名研究对象，平均年龄（59.2±8.3）岁，baPWV异常率为49.7%。调整年龄、糖尿病病程、高血压等混杂因素后，多元线性回归发现体重指数（body mass index，BMI）与baPWV负相关、腰臀比（waist-to-hip ratio，WHR）与baPWV正相关。Logistic回归分析发现与BMI正常组相比，BMI肥胖组baPWV异常（OR=0.59，95% CI：0.44~0.78，P < 0.001）；与WHR正常组相比，WHR肥胖组baPWV异常（OR=1.46，95%CI：1.07~2.00，P < 0.001）；与既无OO也无AO组患者相比，无OO但有AO组患者baPWV异常（OR=1.67，95%CI：1.19~2.35，P=0.003）。 结论 T2DM患者中，AO与baPWV间存在显著的关联，尤其是BMI不肥胖但WHR肥胖的糖尿病患者需要密切随访动脉僵硬度。
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| 关 键 词： | 糖尿病 全身性肥胖 中心性肥胖 动脉僵硬度 |
| 收稿时间： | 2019-03-26 |
| 修稿时间： | 2019-06-25 |
Association of obesity and brachial-ankle pulse wave velocity among type 2 diabetes patients |
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| HUANG Zhe, XU Bei-bei, WANG Xiao-wen, YAO Shan-shan, CAO Gui-ying, LI Man, CAO Ya-ying, TIAN Yao-hua, WU Yao, HUANG Shao-ping, LIU Xiao-fen, QIN Xue-ying, TANG Xun, LI Jin, WU Tao, CHEN Da-fang, HU Yong-hua. Association of obesity and brachial-ankle pulse wave velocity among type 2 diabetes patients[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(9): 1086-1091. doi: 10.16462/j.cnki.zhjbkz.2019.09.014 |
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| Authors: | HUANG Zhe XU Bei-bei WANG Xiao-wen YAO Shan-shan CAO Gui-ying LI Man CAO Ya-ying TIAN Yao-hua WU Yao HUANG Shao-ping LIU Xiao-fen QIN Xue-ying TANG Xun LI Jin WU Tao CHEN Da-fang HU Yong-hua |
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| Affiliation: | 1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;;2. Peking University Medical Informatics Center, Beijing 100191, China;;3. General Office, Fangshan District Center for Disease Control and Prevention, Beijing 102401, China;;4. Department of Chronic Disease, Fangshan District Center for Disease Control and Prevention, Beijing 102488, China |
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| Abstract: | Objective The aim of this study was to investigate associations of overall obesity (OO) and abdominal obesity (AO) with brachial-ankle pulse wave velocity (baPWV) among type 2 diabetes(T2DM) patients. Methods A community-based study for T2DM patients was conducted in rural communities in Beijing.Every patient completed a questionnaire to collect demography, lifestyle and diseases history, and underwent physical examinations, baPWV assessments and blood biochemical tests. Multivariate linear regression was used to assess the relationship between obesity index and baPWV. Abnormal baPWV was defined as patients with baPWV ≥ 1, 700 cm/s. Logistic regression model was performed to explore the risk of abnormal baPWV after adjusting for poetential confounders step by step. Results A total of 2 048 T2DM patients were recruited. The average age was (59.2±8.3) years and total prevalence of abnormal baPWV was 49.7%. After multivariable adjustment, linear regression showed that there was a negative correlation between body mass index(BMI) and baPWV and a positive correlation between waist-to-hip ratio (WHR) and baPWV. Compared to normal weight group, those with BMI ≥ 28 kg/m2 had lower risk of abnormal baPWV (OR=0.59, 95% CI: 0.44-0.78, P < 0.001), but there was an increased risk of 46% among patients with obesity in WHR (OR=1.46, 95% CI: 1.07-2.00, P=0.018). Compared to those without OO and AO, patients without OO but with AO had a 1.67-fold increasesd risk of abnormal baPWV (OR=1.67, 95% CI: 1.19-2.35, P=0.003). Conclusions Abdominal obesity is related with arterial stiffnening among T2DM patients, and it is critical to evaluate arterial stiffness of T2DM patients with abdmonal obesity and normal BMI in order to reduce future risk of cardiovascular diseases. |
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| Keywords: | Diabetes Overall obesity Abdominal obesity Arterial stiffness |
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