| NO、ET-1、Hcy联合检测在冠心病中的诊断价值 |
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| 引用本文： | 邹云法,余文华,徐丽君,邱秀君,郑喆,魏玮. NO、ET-1、Hcy联合检测在冠心病中的诊断价值[J]. 中华全科医学, 2019, 17(7): 1178-1180. DOI: 10.16766/j.cnki.issn.1674-4152.000895 |
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| 作者姓名： | 邹云法 余文华 徐丽君 邱秀君 郑喆 魏玮 |
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| 作者单位： | 1. 开化县临床检验检测中心, 浙江 开化 324300; |
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| 基金项目： | 浙江省医药卫生科技计划项目(2014KYB013) |
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| 摘 要： | 目的探讨内皮功能指标血清一氧化氮(NO)、内皮素-1(ET-1)、同型半胱氨酸(Hcy)联合检测在冠心病中的诊断价值。方法选取2017年3-9月开化县人民医院就诊的232例冠心病患者为观察组,另选取128例健康者为对照组。比较2组受试者的NO、ET-1、Hcy水平,采用受试者工作特征曲线(ROC)下面积(AUC)比较NO、ET-1、Hcy以及联合检测对冠心病的诊断价值,采用单因素分析和logistic回归分析法分析影响冠心病的危险因素。结果观察组的NO水平明显低于对照组,而观察组ET-1、Hcy水平明显高于对照组(均P<0.05);联合检测的AUC值明显高于NO、ET-1、Hcy单独检测的AUC值(均P<0.05);观察组的高血压、糖尿病、血脂异常、吸烟、肥胖发生率明显高于对照组(均P<0.05);以是否为冠心病为因变量,将高血压、糖尿病、血脂异常、吸烟、肥胖以及ET-1、Hcy、NO作为自变量,进行多因素logistic回归分析,结果显示,除高血压、血脂异常、吸烟、肥胖因素外,ET-1、Hcy、NO也可作为评估冠心病的危险因素(均P<0.05),且冠心病的关联强度由高到低依次为ET-1、Hcy、NO。结论 NO、ET-1、Hcy联合检测能够有效诊断冠心病的发生,且可作为冠心病发作风险的有效指标。
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| 关 键 词： | 一氧化氮 内皮素-1 同型半胱氨酸 冠心病 |
| 收稿时间： | 2018-10-20 |
The diagnostic value of combined detection of NO,ET-1 and Hcy in coronary heart disease |
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| Affiliation: | Kaihua County Clinical Examination and Testing Center, Kaihua, Zhejiang 324300, China |
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| Abstract: | Objective To investigate the diagnostic value of nitric oxide (NO), endothelin-1 (ET-1) and homocysteine (Hcy) combined detection in coronary heart disease. Methods A total of 232 coronary heart disease patients as observation group were selected from March 2017 to September 2017 in our hospital, and 128 healthy subjects as control group. The levels of NO, ET-1 and Hcy in the two groups were compared. The detection value of NO, ET-1, Hcy and combined detection of NO, ET-1 and Hcy to coronary heart disease were compared by using the area (AUC) under the receiver operator characteristics curve (ROC). The univariate analysis and logistic regression analysis were used to analyzed risk factors affecting coronary heart disease. Results The level of NO in the observation group was significantly lower than that in the control group, but the level of ET-1 and Hcy in the observation group was significantly higher than those in the control group (all P<0.05). The AUC value of combined detection is significantly higher than the AUC value of NO, ET-1 and Hcy alone (all P<0.05). The incidence of hypertension, diabetes, dyslipidemia, smoking and obesity in the observation group was significantly higher than that in the control group (all P<0.05). Whether as the coronary heart disease as dependent variable, the high blood pressure, diabetes, dyslipidemia, smoking, obesity and ET-1, Hcy, NO as independent variables, multivariable logistic regression analysis, the results showed that the factors in addition to hypertension, dyslipidemia, smoking, obesity, ET-1, Hcy, NO also could be used as evaluating a risk factor for coronary heart disease (all P<0.05), and the correlation strength with coronary heart disease from high to low is ET-1, Hcy, NO. Conclusion The combined detection of NO, ET-1 and Hcy can effectively diagnose the occurrence of coronary heart disease, and it can be used as an effective indicator of the risk of coronary heart disease attack. |
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| Keywords: | Nitric oxide Endothelin-1 Homocysteine Coronary heart disease |
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