Abstract: Objective To investigate the efficacy of Yishen Huoxue decoction combined with electroacupuncture on memory dysfunction after cerebral infarction. Methods According to the digital table method, 84 patients with memory dysfunction after cerebral infarction were divided into control group (42 cases) treated with routine western medicine and donepezil, and combined group (42 cases) treated with Yishen Huoxue Decoction combined with electro-acupuncture on the basis of control group. The differences between TCM syndrome scores, memory scale score, memory quotient, serum MDA, SOD level, mean blood flow velocity of cerebral arteries, clinical efficacy and adverse reactions were compared between the two groups. Results The scores of TCM syndromes in the two groups were lower than those before treatment (all P<0.05), and the decrease in the combination group was more obvious than that in the control group (all P<0.05). After treatment, the scores, recognition, regeneration scores, total scores and memory quotient were significantly higher than those before treatment (all P<0.05). After treatment, the combined group was recorded, recognized, regenerated, counted 1-100, Back number, total score and memory quotient were higher than those before treatment, the difference was statistically significant (all P<0.05). In the combined group, the increase in the scores, recognition, regeneration, count 1-100, back number, total score and memory quotient was more significant than those in the control group (all P<0.05). The levels of MDA and SOD in the two groups were significantly different from those before treatment (all P<0.05). The difference in the changes after treatment in the combined group was more significant than that in the control group (all P<0.05). The blood flow velocity of MCA, ACA, PCA and BA in the combined group were significantly faster than those in the control group (all P<0.05). The clinical effective rate (92.86%) in the combined group was significantly better than that in the control group (71.43%). Conclusion Yishen Huoxue decoction combined with electroacupuncture is a safe and effective treatment for memory dysfunction after cerebral infarction.