| 大鼠支气管扩张症模型研制 |
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| 引用本文： | 万毅刚 曹世宏. 大鼠支气管扩张症模型研制[J]. 实验动物与比较医学, 2000, 20(2): 65-68 |
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| 作者姓名： | 万毅刚 曹世宏 |
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| 作者单位： | [1]南京大学医学院附属鼓楼医院 [2]江苏省中医院 |
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| 基金项目： | 国家自然科学基金!(39830 4 60) |
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| 摘 要： | 为了建立支气管扩张症（简称“支扩”）动物模型,应用大鼠叶支气管结扎并向支气管内注射绿脓杆菌和支气管内直接注射绿脓杆菌两种方法,结果两种方法建立的支扩动物模型在支气管组织病理学特征、支气管分泌物排泌量、支气管行销褒庇录脓杆菌含量等方面与人的相应病变基本一致。
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| 关 键 词： | 支气管扩张症 动物模型 大鼠 病变 |
Establishment of Bronchiectasis Model in Rat |
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| WAN Yi gang,CAO Shi hong,BI Jian ju,ZHU Yu hua. Establishment of Bronchiectasis Model in Rat[J]. Laboratory Animal and Comparative Medicine, 2000, 20(2): 65-68 |
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| Authors: | WAN Yi gang CAO Shi hong BI Jian ju ZHU Yu hua |
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| Affiliation: | WAN Yi gang 1,CAO Shi hong 2,BI Jian ju 2,ZHU Yu hua 2 |
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| Abstract: | To observe the law of bronchiectasis and study the clinical pharmacology, significance of the result of antibiotic and Chinese traditional medicine . A bronchiectasis animal model was established by ligating the rat's bronchus and then injecting ps. Aeruginosa into the bronchial lumen,another one was established by injecting ps, aeruuginosa directly into bronchial lumen without ligation. The results showed that both models were similar to human brochiectasis in histopathology,volume of bronchial secretion and the amount of ps, aeruginosa in bronchial lavage. It was concluded that both model was available for the study of bronchiectasis. |
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| Keywords: | Bronchiectasis Animal model Rat |
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