The potential for Toll-like receptors to collaborate with other innate immune receptors |
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| Authors: | Mukhopadhyay Subhankar Herre Jurgen Brown Gordon D Gordon Siamon |
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| Affiliation: | Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK. |
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| Abstract: | Cells of the innate immune system express a large repertoire of germ-line encoded cell-surface glycoprotein receptors including Toll-like receptors (TLRs). TLRs recognize conserved motifs on microbes and induce inflammatory signals. Evidence suggests that individual members of the TLR family or other non-TLR surface antigens either physically or functionally interact with each other and cumulative effects of these interactions instruct the nature and outcome of the immune response to a particular pathogen. |
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| Keywords: | innate immunity TLRs |
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