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| 雷公藤多甙抑制小鼠腹腔巨噬细胞产生一氧化氮 | |
| 引用本文： | 张永健,谢彦华,苏素文,武占军,王永利,吕占军. 雷公藤多甙抑制小鼠腹腔巨噬细胞产生一氧化氮[J]. 中国药理学与毒理学杂志, 1999, 13(1): 75-76 |
| 作者姓名： | 张永健 谢彦华 苏素文 武占军 王永利 吕占军 |
| 作者单位： | 河北医科大学药理学教研室 |
| 摘 要： | 雷公藤多甙（ｐｏｌｙｇｌｙｃｏｓｉｄｅｏｆＴｒｉｐｔｅｒｙｇｉｕｍｗｉｌｆｏｒｄｉＨｏｏｋ．ｆ．，ＴＷＰ）临床广泛用于治疗类风湿性关节炎等多种自身免疫性疾病，既可抑制细胞免疫又可抑制体液免疫［１］．但其在免疫抑制过程中对一氧化氮合酶（ＮＯＳ）的影响却... |
| 关 键 词： | 雷公藤多甙； 一氧化氮； 巨噬细胞 |
| 收稿时间： | 1997-09-29 |
Polyglycoside of Tripterygium wilfordii Hook. f. inhibited nitric oxide production in mouse peritoneal macrophages |
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| ZHANG Yong Jian,XIE Yan Hua,SU Su Wen,WU Zhan Jun,WANG Yong Li,LU Zhan Jun. Polyglycoside of Tripterygium wilfordii Hook. f. inhibited nitric oxide production in mouse peritoneal macrophages[J]. Chinese Journal of Pharmacology and Toxicology, 1999, 13(1): 75-76 | |
| Authors: | ZHANG Yong Jian XIE Yan Hua SU Su Wen WU Zhan Jun WANG Yong Li LU Zhan Jun |
| Affiliation: | (Department of Pharmacology, 2. Laboratory Animal Center, Hebei Medical University, Shijiazhuang 050017) |
| Abstract: | The effect of polyglycoside of Tripterygium wilfordii Hook. f. (TWP) on NO production in mouse peritoneal Mф was studied. The results indicated that TWP at 2.0 and 4.0 mg·L-1 (in vitro) and 15 and 60 mg·kg-1 (ig) reduced the NO2- production induced by lipopolysaccharide(LPS) 10 mg·L-1 and interferon-γ(IFN- γ) 150 kU·L-1 in cultured peritoneal Mф obtained from C57BL/6 mice. Concanavalin A(Con A) stimulated Mф produced more NO2- than static Mф and the NO2- level was not affected by LPS, IFN γ or TWP. However, if mice were treated by TWP 15 and 60 mg·kg-1 (ig) 4 d before Con A(ip), the NO2- production in Con A stimulated Mф was lowered. These results suggest that TWP decrease NO production through inhibiting the induction of nitric oxide synthase in Mф, which may partially account for its immunosuppressive actions. |
| Keywords: | polyglycoside Tripterygium wilfordii Hook. f. nitric oxide macrophages |
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