| 硫芥诱导HeLa细胞坏死和凋亡的超微结构变化 |
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| 引用本文： | 孙俊,王玉霞,孙曼霁. 硫芥诱导HeLa细胞坏死和凋亡的超微结构变化[J]. 中国药理学与毒理学杂志, 1999, 13(1): 77-78 |
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| 作者姓名： | 孙俊 王玉霞 孙曼霁 |
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| 作者单位： | 军事医学科学院毒物药物研究所,第一军医大学基础部生物学教研室 |
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| 摘 要： | 硫芥是一种细胞毒药物,能烃化生物体内一系列大分子物质,其中核酸是硫芥作用最敏感的靶分子．它还是首次证实有致突变的化学物质［１］．硫芥损伤的短期效应是引起ＤＮＡ断裂,细胞死亡;长期效应是致畸,致癌,致突变．硫芥对人体各种组织都有损伤作用,对皮肤,眼睛,...
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| 关 键 词： | 硫芥 凋亡 坏死 烷化剂 超微结构 |
| 收稿时间： | 1997-12-09 |
Ultrastructure changes in apoptosis and necrosis induced by sulfur mustard in HeLa cells |
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| SUN Jun, WANG Yu-Xia, SUN Man-Ji. Ultrastructure changes in apoptosis and necrosis induced by sulfur mustard in HeLa cells[J]. Chinese Journal of Pharmacology and Toxicology, 1999, 13(1): 77-78 |
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| Authors: | SUN Jun WANG Yu-Xia SUN Man-Ji |
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| Affiliation: | (Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850) |
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| Abstract: | HeLa cells were incubated in vitro with sulfur mustard, and thereafter submitted to transmission electron microscopy to examine the ultrastructure changes caused by different concentrations of sulfur mustard. The results showed that sulfur mustard-injured HeLa cells manifested typical morphological characteristics of apoptosis or necrosis according to the concentration used. Sulfur mustard at low concentration (0.1 mmol·L-1) caused cell apoptosis, whereas at high concentration (1.0 mmol·L-1) induced necrosis. Both the apoptosis and necrosis were developed in time- dependent fashions. |
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| Keywords: | sulfur mustard apoptosis necrosis alkylating agent ultrastructure |
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