| 多希紫杉醇温敏纳米胶束对人胃癌裸鼠移植瘤的靶向治疗作用 |
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| 引用本文： | 沈泽天,杨觅,禹立霞,钱晓萍,刘宝瑞. 多希紫杉醇温敏纳米胶束对人胃癌裸鼠移植瘤的靶向治疗作用[J]. 世界华人消化杂志, 2007, 15(36): 3782-3786 |
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| 作者姓名： | 沈泽天 杨觅 禹立霞 钱晓萍 刘宝瑞 |
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| 作者单位： | 南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所,江苏省南京市,210008;南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所,江苏省南京市,210008;南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所,江苏省南京市,210008;南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所,江苏省南京市,210008;南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤学研究所,江苏省南京市,210008 |
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| 基金项目： | 国家自然科学基金，No 30670958 |
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| 摘 要： | 目的:探讨多希紫杉醇温敏纳米胶束治疗人胃癌裸鼠移植瘤的疗效.方法:采用裸鼠BGC-823胃腺癌动物模型,每组6只,随机分配至设立的多希紫杉醇非热疗和热疗组,多希紫杉醇温敏纳米胶束非热疗和热疗组以及生理盐水对照组等共8组,采用尾静脉给药方式,并恒温43℃对热疗组肿瘤部位进行热导向化疗,动态观察并测定肿瘤的体积、瘤质量抑瘤率,评价治疗效果,并观察实验期间动物的全身情况及相对体质量变化,评价毒副作用.结果:多希紫杉醇温敏纳米胶束热疗组人胃癌移植瘤表现出明显抑制,体积和瘤质量抑瘤率分别为81.5%和85.4%,显著高于多希紫杉醇温敏纳米胶束非靶向组(32.2%,37.5%)和多希紫杉醇注射液组(49.2%,58.0%)(P<0.05),且多希紫杉醇温敏纳米胶束热疗组的小鼠体质量与其他各组比较相对平稳,且饮食、活动正常,对正常组织的毒副作用明显减轻.结论:温敏纳米胶束具有良好的高效低毒体内抗肿瘤作用,作为一种新型的药物载体显示了良好的应用前景.
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| 关 键 词： | 胃癌 温敏纳米胶束 多希紫杉醇 靶向治疗 热疗 |
| 收稿时间： | 2007-07-31 |
| 修稿时间： | 2007-11-05 |
Targeting therapy with docetaxel thermosensitive nano-micelles of human gastric cancer xenografts in nude mice |
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| Ze-Tian Shen,Mi Yang,Li-Xia Yu,Xiao-Ping Qian,Bao-Rui Liu. Targeting therapy with docetaxel thermosensitive nano-micelles of human gastric cancer xenografts in nude mice[J]. World Chinese Journal of Digestology, 2007, 15(36): 3782-3786 |
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| Authors: | Ze-Tian Shen Mi Yang Li-Xia Yu Xiao-Ping Qian Bao-Rui Liu |
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| Abstract: | AIM:To study the curative effects of docetaxel thermosensitive nano-micelles on human gastric cancer xenografts in nude mice. METHODS:Human gastric cancer cell line BGC-823 was implanted into 48 nude mice.Dif- ferent drugs were injected through the caudal vein in eight groups after establishment of the experimental model.Permanent temperature of the tumor was taken in the thermotherapy group.Tumor growth was monitored once every other day,Dynamic viewing and deter- mining the rate of tumor regression in terms of tumor weight and volume were used to evaluate therapeutic efficacy.The side effect was evalu- ated through surveying all the condition and the relative variation in mouse body weight. RESULTS:Tumor growth speed in the docetax- el thermosensitive nano-micelle thermotherapy group was significantly slower than that in the other groups.Tumor volume and weight regression in the docetaxel thermosensitive nano-micelle thermotherapy group were 81.5% and 85.4%,respectively,which were markedly higher than those of the docetaxel thermosensi- rive nano-micelle group (32.2% and 37.5%) and the docetaxel injection group (49.2% and 58.0%) (both P<0.05).The drug side effects and toxicity of docetaxel thermosensitive nano-micelle ther- motherapy were significantly less than those in the other groups. CONCLUSION:Docetaxel thermosensitive nano-micelles show good inhibition of tumor growth,which indicates a favorable potential in clinical application. |
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| Keywords: | Gastric cancer Thermosensitive nano-micelle Docetaxel Targeting therapy Thermotherapy |
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