Tobacco‐induced suppression of the vascular response to dental plaque |
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| Authors: | N. Buduneli D.A. Scott |
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| Affiliation: | 1. Department of Periodontics, School of Dentistry, Ege University, Izmir, Turkey;2. Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA |
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| Abstract: | Cigarette smoking presents oral health professionals with a clinical and research conundrum: reduced periodontal vascular responsiveness to the oral biofilm accompanied by increased susceptibility to destructive periodontal diseases. This presents a significant problem, hampering diagnosis and complicating treatment planning. The aim of this review is to summarize contemporary hypotheses that help to explain mechanistically the phenomenon of a suppressed bleeding response to dysbiotic plaque in the periodontia of smokers. The influence of smoke exposure on angiogenesis, innate cell function, the production of inflammatory mediators including cytokines and proteases, tobacco‐bacteria interactions, and potential genetic predisposition are discussed. |
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| Keywords: | dental plaque innate immunity periodontal diseases tobacco vasculature |
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