The incidence and outcomes of delayed response to cardiac resynchronization therapy |
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| Authors: | Kebei Li MD Zhiyong Qian PhD Xiaofeng Hou MD Yao Wang PhD Yuanhao Qiu BS Yufeng Sheng BS Xuesong Qian BS Yong Zhou BS Jiangang Zou MD PhD |
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| Affiliation: | 1. Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China;2. Department of Cardiology, The First People's Hospital of Zhangjiagang, Affiliated Hospital of Soochow University, Zhangjiagang, Jiangsu, China |
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| Abstract: | 1 Background The incidence and clinical outcomes of delayed response to cardiac resynchronization therapy (CRT) have not been well clarified. We aimed to observe the incidence and prognosis of delayed response and to identify its possible mechanisms. 2 Methods A total of 115 CRT patients were retrospectively analyzed in our study. Patients who met the enrollment criteria were divided into two groups: group A, conventional responders who showed response at 1‐year follow‐up, and group B, delayed responders who showed response after 1‐year follow‐up. CRT response was defined as an absolute increase of ≥10% in left ventricular ejection fraction. 3 Results Fifty‐two patients (61 ± 12 years, 37 male) experienced conventional response to CRT and 17 patients (63 ± 11 years, 10 male) experienced delayed response. The mean follow‐up time was 5.2 ± 2.4 years. The incidence of delayed response was 14.8% (17/115). All‐cause mortality and hospitalization rates for heart failure were similar for delayed and conventional responders. Multivariate logistic regression analysis revealed that scar burden > 35% was an independent predictor of CRT delayed response (odds ratio 8.794, P = 0.038). 4 Conclusions A significant proportion of patients demonstrated delayed response to CRT. The delayed responders had a good prognosis that was similar to that of conventional responders. More scar burden might be related to the incidence of delayed response. |
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| Keywords: | cardiac resynchronization therapy delayed response mortality scar burden |
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