| bcl-2基因的表达在卵巢恶性肿瘤多药耐药中的意义 |
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| 引用本文： | 田晓红,齐凤琴. bcl-2基因的表达在卵巢恶性肿瘤多药耐药中的意义[J]. 新乡医学院学报, 2007, 24(4): 362-363 |
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| 作者姓名： | 田晓红 齐凤琴 |
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| 作者单位： | 新乡市中医院妇产科; 封丘县计划生育指导站 |
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| 摘 要： | 目的探讨bcl-2基因与卵巢恶性肿瘤细胞多药耐药的关系。方法采用体外药敏实验(MTT法)检测药物敏感性,免疫组织化学方法检测45例卵巢恶性肿瘤组织bcl-2蛋白的表达,并对相关的临床病理因素进行分析。结果卵巢恶性肿瘤组织中bcl-2蛋白表达阳性率为55.6%,且不同病理类型、临床分期和术后残留病灶大小与卵巢恶性肿瘤组织中bcl-2蛋白的表达无关(P>0.05),bcl-2的表达与卵巢恶性肿瘤的耐药性呈显著的正相关(P<0.05)。结论bcl-2基因可能参与了卵巢恶性肿瘤组织的化疗耐药性,bcl-2蛋白表达的检测可以预测卵巢恶性肿瘤化疗敏感性。
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| 关 键 词： | 卵巢恶性肿瘤 多药耐药 bcl-2基因 免疫组织化学 |
| 文章编号： | 1004-7239（2007）04-0362-02 |
| 收稿时间： | 2007-04-06 |
| 修稿时间： | 2007-04-06 |
Expression of bcl-2 gene on multidrug resistance of ovarian malignancy |
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| TIAN Xiao-hong,QI Feng-qin. Expression of bcl-2 gene on multidrug resistance of ovarian malignancy[J]. Journal of Xinxiang Medical College, 2007, 24(4): 362-363 |
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| Authors: | TIAN Xiao-hong QI Feng-qin |
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| Affiliation: | 1. Department ofgynaecology and obstetrics, the Traditional Chinese Medical Hospital of Xinxiang City, Xinxiang 453000, China; 2. Family Planning Guidance Station of Fengqiu County, Fengqiu 453300, China |
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| Abstract: | Objective To explore the relation of the expression of bcl-2 to multidrug resistance of ovarian malignancy.Methods Forty-five cases of ovarian malignancy were tasted with methyl thiazolyl tetrazolium assay to evaluate their chemoresistance.The expression of bcl-2 gene above examined with immunohistochemical assay.The related clinical pathological factor were analyzed.Results The positive rate of bcl-2 in ovarian malignancy tissue was 55.6%.The expression of bcl-2 in ovarian malignancy tissue was not associated with pathological type,clinical stage and the size of reliquus focus(P>0.05).The expression of bcl-2 was positive correlative with the drug resistance of ovarian malignancy(P<0.05).Conclusion Bcl-2 possiblly participate in drug resistance of chemotherapy of ovarian malignancy,and the expression of bcl-2 can predict the sensitivity of chemotherapy. |
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| Keywords: | ovarian malignancy multidrug resistance bcl-2 gene immunohistochemistry |
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