| 血清内皮抑素与冠心病合并2型糖尿病病人冠状动脉病变严重程度的关系研究 |
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| 引用本文： | 张小花,宗雪萍,管丽娟. 血清内皮抑素与冠心病合并2型糖尿病病人冠状动脉病变严重程度的关系研究[J]. 蚌埠医学院学报, 2021, 46(3): 363-367. DOI: 10.13898/j.cnki.issn.1000-2200.2021.03.023 |
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| 作者姓名： | 张小花 宗雪萍 管丽娟 |
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| 作者单位： | 四川省成都市第五人民医院 心内科, 611130 |
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| 摘 要： | 目的:探讨血清内皮抑素(ES)与冠心病(CHD)合并2型糖尿病(T2DM)病人冠状动脉钙化程度的关系.方法:纳入115例CHD病人,其中合并T2DM者60例(观察组),无T2DM者55例(对照组).采用酶联免疫吸附试验测定2组病人血清ES水平,通过CT获得冠状动脉钙化积分(CACS).结果:观察组血清ES水平明显高于对...
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| 关 键 词： | 冠心病 2型糖尿病 冠状动脉钙化 内皮抑素 |
| 收稿时间： | 2019-12-03 |
Relationship between serum endostatin and severity of coronary artery lesions in patients with coronary heart disease complicated with type 2 diabetes mellitus |
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| ZHANG Xiao-hua,ZONG Xue-ping,GUAN Li-juan. Relationship between serum endostatin and severity of coronary artery lesions in patients with coronary heart disease complicated with type 2 diabetes mellitus[J]. Journal of Bengbu Medical College, 2021, 46(3): 363-367. DOI: 10.13898/j.cnki.issn.1000-2200.2021.03.023 |
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| Authors: | ZHANG Xiao-hua ZONG Xue-ping GUAN Li-juan |
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| Affiliation: | Department of Cardiology, The Fifth People's Hospital of Chengdu, Chengdu Sichuan 611130, China |
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| Abstract: | ObjectiveTo assess the relationship between serum endostatin(ES) and coronary artery calcification(CAC) in coronary heart disease(CHD) complicated with type 2 diabetes mellitus(T2DM) patients.MethodsAmong 115 patients with CHD, 60 cases complicated with T2DM and 55 cases complicated without T2DM were divided into the observation group and control group, respectively.The serum ES levels in two groups were detected using enzyme-linked immunosorbent assay, and the coronary artery calcium score(CACS) scores were obtained using CT.ResultsThe serum ES level in observation group was significantly higher than that in control group(P < 0.01).The differences of the serum ES levels among the patients with 0, single, double and triple branches lesions in observation group were statistically significant(P < 0.01), while the differences of those in control group were not statistically significant(P>0.05).The CACS in observation group was significantly higher than that in control group(P < 0.01).According to the CACS distribution, the serum ES levels in observation group were higher than that in control group(P < 0.05 to P < 0.01).The optimal cutoff value of ES for CACS >100 points was 69.18 ng/mL, and the sensitivity, specificity, AUC and 95%CI were 62.9%, 75.6%, 0.700 and 0.604 to 0.796, respectively(P < 0.01).The results of multiple logistic regression analysis showed that the ES level was an independent risk factors of significant calcification and obstruct of coronary artery.ConclusionsThe serum ES level is closely related to the number of coronary artery lesions and the degree of calcification in patients with CHD complicated with T2DM, which may be used as a monitoring index for the progression of coronary atherosclerosis. |
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