| 孕期体质量增值、血脂水平与孕妇妊娠期高血压靶器官损害及妊娠结局的关联性分析 |
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| 引用本文： | 黄思玲,桑琳. 孕期体质量增值、血脂水平与孕妇妊娠期高血压靶器官损害及妊娠结局的关联性分析[J]. 蚌埠医学院学报, 2021, 46(7): 907-912. DOI: 10.13898/j.cnki.issn.1000-2200.2021.07.017 |
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| 作者姓名： | 黄思玲 桑琳 |
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| 作者单位： | 安徽省合肥市第二人民医院 妇产科, 230032 |
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| 摘 要： | 目的:探讨孕期体质量增值、血脂水平与孕妇妊娠期高血压靶器官损害及妊娠结局的关联性.方法:选取85例妊娠期高血压孕妇作为研究组,随机选取同期60名正常孕妇作为对照组.统计比较2组一般资料,探讨妊娠期高血压发病的危险因素,比较研究组不同靶器官损害情况病人的孕期体质量增值、血脂水平,并分析孕期体质量增值、血脂水平与靶器官损害...
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| 关 键 词： | 妊娠期高血压 孕期体质量增值 血脂 靶器官损害 妊娠结局 |
| 收稿时间： | 2020-09-30 |
Correlation analysis of the body mass gain and blood lipid level during pregnancy with target organ damage of pregnancy hypertension and pregnancy outcome |
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| HUANG Si-ling,SANG Lin. Correlation analysis of the body mass gain and blood lipid level during pregnancy with target organ damage of pregnancy hypertension and pregnancy outcome[J]. Journal of Bengbu Medical College, 2021, 46(7): 907-912. DOI: 10.13898/j.cnki.issn.1000-2200.2021.07.017 |
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| Authors: | HUANG Si-ling SANG Lin |
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| Affiliation: | Department of Obstetrics and Gynecology, Hefei Second People's Hospital, Anhui Hefei 230032, China |
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| Abstract: | ObjectiveTo explore the correlation of the body mass gain and blood lipid level during pregnancy with target organ damage of pregnancy hypertension and pregnancy outcome.MethodsA total of 85 pregnant women with hypertension during pregnancy were set as the study group, and 60 normal pregnant women during the same period were randomly selected as the control group.The general data of two groups were statistically compared, and the risk factors of hypertension during pregnancy were investigated.The body mass gain and blood lipid level during pregnancy of patients with different target organ damage in study group were compared, and the correlation between the body mass gain, blood lipid level during pregnancy and target organ damage were analyzed.The study group was followed up to the end of pregnancy, and the pregnancy outcome of the study group was counted.The baody mass gain and blood lipid level during pregnancy were compared between patients with good and poor pregnancy outcomes and the efficacy of body mass gain and blood lipid level during pregnancy in assessing target organ damage and predicting poor pregnancy outcome were explored.ResultsBefore pregnancy, the body mass index(BMI), body mass gain during pregnancy, family history of hypertension, and levels of triglyceride(TG), total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) in study group were higher than those in control group(P<0.01), and the high-density lipoprotein cholesterol(HDL-C) level in study group was lower than that in control group(P<0.05).The BMI before pregnancy, body mass gain during pregnancy, family history of hypertension, and levels of TG, TC, HDL-C and LDL-C were the influencing factors of hypertension during pregnancy(P<0.05 to P<0.01).The body mass gain during pregnancy, and levels of TG, TC and LDL-C were positively correlated with the target organ damage(P<0.01), and the HDL-C level was negatively correlated with target organ damage(P<0.05).The area under the curve (AUC) of body mass gain during pregnancy, and levels of TG, TC, HDL-C and LDL-C in the combined assessment of target organ damage was 0.879, which was greater than a single assessment of each index, and the best evaluation sensitivity and specificity were 73.82% and 92.40%, respectively.The body mass gain during pregnancy, and levels of TG, TC and LDL-C in patients with poor pregnancy outcome were higher than those in patients with good pregnancy outcome(P<0.05), and the HDL-C level in patients with poor pregnancy outcome was lower than that in patients with good pregnancy outcome(P<0.05).The AUC of body mass gain during pregnancy, and levels of TG, TC, HDL-C and LDL-C in the combined assessment of poor pregnancy outcome was 0.932, which was greater than a single assessment of each index, and the best evaluation sensitivity and specificity were 88.89% and 88.06%, respectively.ConclusionsThe body mass gain and blood lipid level during pregnancy are closely related to the onset of pregnancy-induced hypertension and target organ damage, and can assist the clinical assessment of target organ damage and predict the risk of adverse pregnancy outcome. |
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