Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis |
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| Authors: | Hirst Robert A Gosai Bejal Rutman Andrew Andrew Peter W O'Callaghan Christopher |
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| Affiliation: | Department of Child Health, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicestert Royal Infirmary, PO Box 65, Leicester LE2 7LX, U.K. rah9@le.ac.uk |
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| Abstract: | Streptococcus pneumoniae meningitis remains a disease with a poor outcome for the patient. A region of the brain that has been neglected in the study of meningitis is the ependyma, which has been identified as a location of adult pluripotent cells. In this study we have used a rat model of meningitis to examine whether the ependymal layer is affected by S. pneumoniae. The effects included localized loss of cilia, a decrease of the overall ependymal ciliary beat frequency, and damage to the ependymal ultrastructure during meningitis. In conclusion, loss of ependymal cells and ciliary function exposes the underlying neuronal milieu to host and bacterial cytotoxins and this is likely to contribute to the neuropathology commonly observed in pneumococcal meningitis. |
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