| 胃癌No.14v组淋巴结转移的危险因素及预后分析 |
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| 引用本文： | 刘金禄,覃新干,利长华,罗义欢,陈俊强. 胃癌No.14v组淋巴结转移的危险因素及预后分析[J]. 中国癌症防治杂志, 2020, 12(1): 69-74. DOI: 10.3969/j.issn.1674-5671.2020.01.12 |
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| 作者姓名： | 刘金禄 覃新干 利长华 罗义欢 陈俊强 |
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| 作者单位： | 广西医科大学第一附属医院胃肠腺体外科 |
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| 基金项目： | 广西科技计划重点研发项目(桂科AB18126058);广西自然科学基金项目(2016GXNSFAA380180);广西卫生和计划生育委员会自筹经费科研课题(Z2015526);广西医科大学青年科学基金项目(GXMUYSF201502)。 |
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| 摘 要： | 目的 探讨胃癌No.14v组淋巴结转移的危险因素及对预后的影响。方法 回顾性分析72例行胃癌D2根治术+No.14v组淋巴结清扫患者的临床资料。采用Logistic回归分析影响No.14v组淋巴结转移的因素，Cox回归分析No.14v组淋巴结转移与预后的关系。结果 No.14v组淋巴结转移率为25.0%（18/72）。Logistic回归分析显示，Borromann分型Ⅲ~Ⅳ型（OR=81.508，95%CI：4.805~1 382.635，P=0.002）、远处转移（OR=11.494，95%CI：1.085~121.723，P=0.043）和TNM分期Ⅲ~Ⅳ期（OR=8.101，95%CI：1.355~48.437，P=0.005）是影响No.14v组淋巴结转移的独立危险因素。No.14v组淋巴结转移组患者的中位生存时间低于非转移组（22个月 vs 33 个月，χ2=22.737，P<0.001）；多因素Cox回归分析显示，No.14v组淋巴结转移是影响患者总生存期的独立影响因素（HR=2.881，95%CI：1.222~6.793，P=0.016）。 结论 No.14v组淋巴结转移的胃癌患者预后较差，Borromann分型Ⅲ~Ⅳ型、远处转移及TNM分期Ⅲ~Ⅳ期是No.14v组淋巴结转移的独立危险因素。
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| 关 键 词： | 胃癌 No.14v组淋巴结 危险因素 预后 |
Risk factors and prognostic analysis of lymph node metastasis in No.14v group in gastric cancer |
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| LIU Jinlu,QIN Xingan,LI Changhua,LUO Yihuan,CHEN Junqiang. Risk factors and prognostic analysis of lymph node metastasis in No.14v group in gastric cancer[J]. Journal of Chinese Medical Abstracts·Oncology, 2020, 12(1): 69-74. DOI: 10.3969/j.issn.1674-5671.2020.01.12 |
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| Authors: | LIU Jinlu QIN Xingan LI Changhua LUO Yihuan CHEN Junqiang |
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| Affiliation: | (Department of Gastrointestinal Gland Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Objective To investigate the risk factors and to perform prognostic analysis of lymph node metastasis in the No.14 v group in gastric cancer. Methods The clinical data of 72 gastric cancer patients who underwent radical gastrectomy with lymph node in the No.14 v group dissection were analyzed retrospectively. Logistic regression was used to analyze the factors affecting lymph node metastasis in the No.14 v group,Cox regression was used to analyze the relationship between lymph node metastasis in the No.14 v group and prognosis. Results The lymph node metastasis rate in the No.14 v group was 25.0%(18/72). Logistic regression analysis showed that Borromann classification Ⅲ-Ⅳ(OR=81.508,95%CI:4.805-1 382.635,P=0.002),distant metastasis(OR=11.494,95%CI:1.085-121.723,P=0.043),and TNM stages Ⅲ-Ⅳ(OR = 8.101,95%CI :1.355-48.437,P= 0.005) were independent risk factors affecting lymph node metastasis in the No.14 v group. The median overall survival of patients with lymph node metastasis in the No.14 v group was lower than that in the non-metastatic group(22 months vs 33 months,χ~2= 22.737,P<0.001). Multivariate Cox regression analysis showed that lymph node metastasis in the No.14 v group was an independent influencing factor for the overall survival of patients(HR=2.881,95%CI:1.222-6.793,P=0.016). Conclusions Patients with lymph node metastasis in the No.14 v group have a poor prognosis in gastric cancer,and the independent risk factors for lymph node metastasis in the No.14 v group include Borromann classificationⅢ-Ⅳ,distant metastasis,and TNM stage Ⅲ-Ⅳ. |
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| Keywords: | Gastric cancer No.14v lymph node Risk factors Prognosis |
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