| 艰难梭菌耐药性及耐药机制研究进展 |
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| 引用本文： | 范欣,陈新飞,肖盟,徐英春. 艰难梭菌耐药性及耐药机制研究进展[J]. 临床荟萃, 2018, 33(5): 377. DOI: 10.3969/j.issn.1004-583X.2018.05.003 |
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| 作者姓名： | 范欣 陈新飞 肖盟 徐英春 |
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| 作者单位： | 1.首都医科大学附属北京朝阳医院 感染和临床微生物科， 北京100020；2.中国医学科学院北京协和医院检验科
侵袭性真菌病机制研究与精准诊断北京市重点实验室， 北京100730 |
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| 基金项目： | 国家自然科学基金青年科学基金：中国引起抗生素相关性腹泻艰难梭菌A、B毒素毒力及与菌株基因背景关联性研究（81501807）；北京协和医院中青年科研基金：北京市艰难梭菌多中心分子流行病学监测及基因组多态性研究（pumch-2016-1.2） |
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| 摘 要： | 艰难梭菌是导致抗生素相关性腹泻和医院感染性腹泻的最主要病原菌。在欧美等发达国家及地区，艰难梭菌感染都有较高的发病率和死亡率，因此受到高度关注。相比，国内艰难梭菌的研究数据还相对匮乏，尤其临床对其对常用抗生素的耐药性还认识不足。因此，本文就艰难梭菌的耐药性和耐药机制的最新研究进展进行综述。
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| 关 键 词： | 艰难梭菌 抗药性 |
Research development on drug resistance and mechanisms of Clostridium difficile |
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| Fan Xin,Chen Xinfei,Xiao Meng,Xu Yingchun. Research development on drug resistance and mechanisms of Clostridium difficile[J]. Clinical Focus, 2018, 33(5): 377. DOI: 10.3969/j.issn.1004-583X.2018.05.003 |
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| Authors: | Fan Xin Chen Xinfei Xiao Meng Xu Yingchun |
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| Affiliation: | 1.Department of Infectious Diseases and Clinical Microbiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; 2.Department of Clinical Laboratory, Bejing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China; |
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| Abstract: | Clostridium difficile is the major cause of antibiotic associated diarrhea and hospital acquired infectious diarrhea. In developed countries and regions, C. difficile infections have high morbidity and mortality and have received broad attention. In comparison, China's data on C. difficile, especially on its resistance to commonly used antibiotics, is limited. Hence, this paper reviews the latest research progress on resistant status of C. difficile and its resistant mechanism. |
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| Keywords: | Clostridium difficile drug resistance |
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