| 应用高频超声评价昆仙胶囊对膝骨关节炎的疗效 |
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| 引用本文： | 齐晅,孙超,田玉,丁萌. 应用高频超声评价昆仙胶囊对膝骨关节炎的疗效[J]. 临床荟萃, 2018, 33(4): 306. DOI: 10.3969/j.issn.1004-583X.2018.04.008 |
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| 作者姓名： | 齐晅 孙超 田玉 丁萌 |
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| 作者单位： | 河北医科大学第二医院风湿免疫科，河北 石家庄 050000 |
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| 基金项目： | 河北省卫生厅科研基金项目（ZL20140070） |
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| 摘 要： | 目的 通过高频超声探查双膝关节软骨变化评价昆仙胶囊对膝骨关节炎（KOA）患者的疗效。方法 收集KOA患者43例，随机分为对照组（24例）和治疗组（19例），对照组应用盐酸氨基葡萄糖＋美洛昔康；治疗组在对照组用药基础上加用昆仙胶囊。两组分别于治疗前及治疗3个月对膝关节疼痛程度进行视觉模拟评分法（VAS）评分，同时应用超声探查股骨滑车沟（TG）、股骨内侧髁（MFC）和股骨外侧髁（LFC）处软骨，对软骨损伤程度进行分级。结果 与治疗前相比，治疗组与对照组治疗3个月VAS评分均降低，差异有统计学意义（P＜0.01），对照组治疗3个月MFC超声分级、LFC超声分级无明显变化，TG超声分级、超声分级总分增加（P＜0.05），治疗组治疗3个月TG超声分级、MFC超声分级、LFC超声分级及超声分级总分均无明显变化。与对照组相比，治疗组VAS评分下降更明显（P＜0.01），TG超声分级、超声分级总分差异有统计学意义（P＜0.05），MFC超声分级、LFC超声分级变化差异无统计学意义。结论 昆仙胶囊联合盐酸氨基葡萄糖和美洛昔康治疗KOA可以缓解疼痛，延缓疾病进展，高频超声评估关节软骨损伤程度可作为KOA疗效评估方法，具有一定的临床推广价值。
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| 关 键 词： | 骨关节炎 膝 昆仙胶囊 软骨退化 高频超声 |
Evaluation of curative effect of KunXian capsule on knee osteoarthritis by high frequency ultrasound |
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| Qi Xuan,Sun Chao,Tian Yu,Ding Meng. Evaluation of curative effect of KunXian capsule on knee osteoarthritis by high frequency ultrasound[J]. Clinical Focus, 2018, 33(4): 306. DOI: 10.3969/j.issn.1004-583X.2018.04.008 |
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| Authors: | Qi Xuan Sun Chao Tian Yu Ding Meng |
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| Affiliation: | Department of Rheumatology and Immunology the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China |
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| Abstract: | Objective To evaluate the curative effect of Kun Xian capsule on knee osteoarthritis (KOA) by the changes of the knee joint cartilage with high frequency ultrasound.Methods A total of 43 cases of KOA patients were enrolled and randomly divided into control group (n=24) and treatment group(n=19). The control group were treated with glucosamine hydrochloride plus meloxicam, while the treatment group were treated with Kun Xian capsule on the basis of the control group. The degree of knee joint pain in all patients was assessed by visual analogue scoring（VAS） before treatment and 3 months after treatment. In the meantime, the cartilage of the femoral trochlear groove(TG), medial femoral condyle(MFC) and lateral femoral condyle(LFC) were detected by ultrasound to grade the degrees of cartilage injury. Results Compared with the conditions before treatment，the VAS scores of the treatment group and the control group decreased after 3 month treatment(P<0.01), while, there was no significant change between MFC and LFC ultrasonic grade after 3 month treatment in the control group. However, TG and the total score of ultrasonic grade witnessed increases(P<0.05). In the treatment group， there was no significant change between TG，MFC，LFC and the total score of ultrasonic grade after 3 month treatment. Compared with the control group， the VAS score of the treatment group decreased more obviously(P<0.01) , TG and the total ultrasonic score of the treatment group were significantly lower than those of the control group(P<0.05), and there was no significant difference between MFC and LFC.Conclusion Kun Xian capsule combined with glucosamine hydrochloride and meloxicam can relieve pain and delay disease progression in KOA. High frequency ultrasound can be applied to evaluate the degree of articular cartilage injury as a method to evaluate the curative effect of KOA， which can be popularized in clinical application. |
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| Keywords: | osteoarthritis knee kunxian capsule cartilage degeneration high frequency ultrasound |
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