| 518例恶性皮肤肿瘤及癌前病变的回顾性分析 |
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| 引用本文： | 例恶性皮肤肿瘤及癌前病变的回顾性分析. 518例恶性皮肤肿瘤及癌前病变的回顾性分析[J]. 首都医科大学学报, 2018, 39(4): 602-606. DOI: 10.3969/j.issn.1006-7795.2018.04.023 |
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| 作者姓名： | 例恶性皮肤肿瘤及癌前病变的回顾性分析 |
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| 作者单位： | 北京大学第三医院皮肤科, 北京 100191 |
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| 摘 要： | 目的 分析北京大学第三医院皮肤科恶性皮肤实体肿瘤以及癌前病变的发病特点，为其可能的发病机制、预防措施提供线索。方法 采用系统性回顾的方法对2013至2016年间518例恶性皮肤实体肿瘤以及癌前病变患者的临床病理资料进行分析。结果 非黑素瘤性皮肤肿瘤（non-melanoma skin cancer，NMSC）共343例，癌前病变162例，NMSC中基底细胞癌206例、鳞状细胞癌73例、角化棘皮瘤47例，基底细胞癌、各亚型鳞状细胞癌门诊就诊比例呈逐年升高。NMSC男女比例差异不大，均以老年人（≥ 60岁）为主。基底细胞癌好发于头面部（79.6%），以鼻部为著，侵袭性鳞癌好发于头面部（61.1%），原位鳞癌好发于躯干（34.6%）。癌前病变中日光性角化最多。结论 北京大学第三医院NMSC门诊就诊比逐年升高，以头面部基底细胞癌增长最快，且以老年患者为主，提示关注环境危险因素（紫外线、汽车尾气、PM2.5）对恶性皮肤肿瘤发病的影响，以及早期预防教育、早期筛查的必要性。
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| 关 键 词： | 恶性皮肤肿瘤 癌前病变 回顾性分析 |
| 收稿时间： | 2018-03-07 |
Skin cancer and precancerous skin lesions: retrospective analysis of 518 cases |
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| Liu Zilian,Zhang Qian,Wu Wenting,Zhang Chunlei,Ma Chuan. Skin cancer and precancerous skin lesions: retrospective analysis of 518 cases[J]. Journal of Capital Medical University, 2018, 39(4): 602-606. DOI: 10.3969/j.issn.1006-7795.2018.04.023 |
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| Authors: | Liu Zilian Zhang Qian Wu Wenting Zhang Chunlei Ma Chuan |
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| Affiliation: | Department of Dermatology, Peking University Third Hospital, Beijing 100191, China |
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| Abstract: | Objective To study the characteristics of skin cancer and precancerous lesions and elucidate possible clues for the pathogenesis and provide feasible preventive measures. Methods The statistical analysis was performed based on the clinical dataset during 2013 to 2016, taken from the Dermatology Department of Peking University Third Hospital. Results The database summarized in-total 343 Non-melanoma skin cancer(NMSC) cases, in which the number of basal cell carcinoma(BCC) was 206, squamous cell carcinoma (SCC) 73 and actinic keratosis(AK) 81. The constituent ratio of BCC, invasive SCC and SCC in situ increased during the time. In general, no significant differences were found between the genders, where the elderly (over 60 years) dominate all types of NMSC. In details, BCC has a predilection to be found on the head and neck (79.6%), especially on the nose, similarly invasive SCC mainly occurred on the head and neck (61.1%). SCC in situ, on the other hand, mainly appeared on the trunk (34.6%). In addition, there were in-total 162 precancerous patients, in which the AK takes relatively big ratio. Conclusion The statistical analysis of NMSC from the database of our hospital was performed, indicating the constituent ratio of NMSC increased, in which BCC increased rapidly during the 4 years(2013-2016), involving mostly the elderly. The result suggests the environmental risk factors (UV, exhaust, PM2.5, etc.) which may induce the malignant skin tumors and further reveals the necessity to have early prevention education and early screening of skin cancer. |
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| Keywords: | skin cancer precancerous lesions retrospective studies |
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