| 基于紫外吸收及导数光谱监测乙酸钠催化合成阿司匹林的反应研究 |
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| 引用本文： | 基于紫外吸收及导数光谱监测乙酸钠催化合成阿司匹林的反应研究. 基于紫外吸收及导数光谱监测乙酸钠催化合成阿司匹林的反应研究[J]. 首都医科大学学报, 2018, 39(5): 710-714. DOI: 10.3969/j.issn.1006-7795.2018.05.016 |
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| 作者姓名： | 基于紫外吸收及导数光谱监测乙酸钠催化合成阿司匹林的反应研究 |
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| 作者单位： | 首都医科大学药学院实验教学中心, 北京 100069 |
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| 基金项目： | 北京市教育委员会人才培养质量建设项目（PXM2017_014226_000073），首都医科大学2015年度校长基金（2015JYY28）。 |
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| 摘 要： | 目的 采用乙酸钠为催化剂，对合成阿司匹林的反应体系进行监测研究。方法 分别建立阿司匹林和水杨酸在289 nm和308 nm处的紫外二阶导数值与浓度的标准工作曲线，实时监测不同温度条件下反应体系中阿司匹林和水杨酸的含量变化情况。结果 当控制合成阿司匹林的反应温度分别为45、55、65和75℃时，反应完成的时间约为20、10、4和3 min。结论 随着反应温度提高，乙酸钠催化合成阿司匹林反应的时间显著变短。采用紫外吸收及导数光谱法，可以实现对阿司匹林合成过程的监测和判断反应终点。
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| 关 键 词： | 阿司匹林 乙酸钠 紫外吸收光谱 二阶导数光谱 |
| 收稿时间： | 2018-01-25 |
Research on monitoring synthesis systems of aspirin with sodium acetate as the catalyst by ultraviolet absorption and derivative spectrometry |
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| Shao Jianqun,Tang Jingcheng,Xu Yanxia,Zhang Feng. Research on monitoring synthesis systems of aspirin with sodium acetate as the catalyst by ultraviolet absorption and derivative spectrometry[J]. Journal of Capital Medical University, 2018, 39(5): 710-714. DOI: 10.3969/j.issn.1006-7795.2018.05.016 |
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| Authors: | Shao Jianqun Tang Jingcheng Xu Yanxia Zhang Feng |
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| Affiliation: | Experimental Teaching Center, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China |
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| Abstract: | Objective To research on monitoring synthesis systems of aspirin with sodium acetate as the catalyst. Methods Each standard work curve of aspirin and salicylic acid were established with second derivative value against concentration at the wavelengths of 289 nm and 308 nm. Under different temperatures, the real-time content of aspirin and salicylic acid in synthesis reaction system were monitored. Results When the reaction temperature was 45,55,65 and 75℃, the complete reaction times were about 20, 10, 4 and 3 min individually. Conclusion The length of the synthesis of aspirin reaction time was significantly shorter with the higher reaction temperature by using sodium acetate as catalyst. The ultraviolet absorption and derivative spectrometry can be achieved on the monitoring and judging aspirin synthesis reaction endpoint. |
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| Keywords: | aspirin sodium acetate ultraviolet absorption spectrum second derivative spectrum |
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