Prospective determination of plasma imipenem concentrations in critically ill children |
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| Authors: | Giannoni Eric Moreillon Philippe Cotting Jacques Moessinger Adrien Bille Jacques Décosterd Laurent Zanetti Giorgio Majcherczyk Paul Bugnon Denis |
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| Affiliation: | Department of Pediatrics, CHUV, CH-1011 Lausanne, Switzerland. |
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| Abstract: | Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4x at peak and >10x at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy. |
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