Lesion characteristics evaluated by intravascular ultrasound in patients with endogenous collateral wind
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摘要: 目的 比较冠心病不同中医证型的血管内超声（IVUS）特征。方法 选择做血管内超声（IVUS）检查的冠心病患者28例，按中医辨证分为血瘀证组（n=10）和络风内动证组(n=18)。采用IVUS测定两组“罪犯”病变斑块面积、外弹力膜（EEM）面积、斑块负荷、高危斑块发生率、正向重构、负向重构和重构指数（RI）等指标，使用SPSS11.0软件包，对比分析两组资料。结果 络风内动证组“罪犯”病变处的斑块面积、EEM面积和斑块负荷均显著大于血瘀证组（分别P<0.01，P<0.01和P<0.05），高危斑块发生率和重构指数（RI）也明显高于血瘀证组（均P<0.05）；正重构更常见于络风内动证组（P<0.05），负重构常见于血瘀证组（P<0.05）。结论 络风内动证组患者冠状动脉粥样硬化斑块破裂的可能性更高。Abstract: AIM To compare the lesion characteristics measured by intravascular ultrasound (IVUS) in different types of syndrome by traditional Chinese medicine in patients of coronary artery diseases. METHODS Twendty-eight consecutive patients of coronary artery disease confirmed by IVUS was made the differential diagnosis as blood stasis group (n=10) and endogenous collateral wind group (n=18). The indexes such as area of plaques in criminal lesions, the area of extra-elasticity membrane (EEM), plaque burden, the incidence of high-risk plaques, the positive or negative remodeling percentage and remodeling index (RI) were measured by IVUS. Analyses were performed by statistical package SPSS11.0. RESULTS The area of plaques in criminal lesions, the area of EEM and plaque burden in endogenous collateral wind group were significantly larger than those in blood stasis group (P<0.01, P<0.01, P<0.05, respectively). The incidence of high-risk plaques and RI in endogenous collateral wind group were markedly higher than those in blood stasis group (P<0.05, P<0.05, respectively). More positive remodeling was observed in endogenous collateral wind group (P<0.05) whild the more negative remodeling was seen in blood stasis group (P<0.05). CONCLUSION The coronary arterial atherosclerotic plaques in the patients with endogenous collateral wind may be more unstable.
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