| 肝脂酶基因-514C/T变异对血脂的影响 |
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| 引用本文： | 姚友权,徐力辛,熊术道. 肝脂酶基因-514C/T变异对血脂的影响[J]. 蚌埠医学院学报, 2007, 32(4): 431-434 |
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| 作者姓名： | 姚友权 徐力辛 熊术道 |
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| 作者单位： | 1. 温州医学院第一附属医院心内科, 浙江温州 325000;2. 温州医学院第一附属医院医科所, 浙江温州 325000 |
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| 摘 要： | 目的: 探讨肝脂酶(HL)基因启动子-514C/T变异是否影响血脂水平。方法: 选入符合录用标准者322例作血脂测定,从全血中用DNA试剂盒提取DNA,采用聚合酶链式反应-限制性片断多态性方法检测HL基因多态性。结果: 在调整年龄和体重指数(BMI)后,HL-514C/T基因型对血清高密度脂蛋白胆固醇(HDL-C)的水平影响有统计学意义(P<0.01),其高低是T/T+T/C>C/C,这种效应与男性关系明显(P<0.01),但与女性关系不明显。结论: 肝脂酶基因-514C/T变异可影响血脂水平,且存在男女性别差异,各HL基因型的分布无性别差异。
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| 关 键 词： | 血脂蛋白过多 肝脂酶 基因 调节 变异 |
| 文章编号： | 1000-2200（2007）04-0431-04 |
| 收稿时间： | 2006-08-30 |
| 修稿时间： | 2006-08-30 |
Influence of hepatic lipase gene C-514T variants on blood lipids |
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| YAO You-quan,XU Li-xin,XIONG Shu-dao. Influence of hepatic lipase gene C-514T variants on blood lipids[J]. Journal of Bengbu Medical College, 2007, 32(4): 431-434 |
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| Authors: | YAO You-quan XU Li-xin XIONG Shu-dao |
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| Affiliation: | 1. Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China |
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| Abstract: | Objective:To investigate whether the promoter 514C/T of hepatic lipase(HL)variants affect blood lipids level.Methods:Three hundred and twelve subjects were studied.The serum lipid and apolipoprotein were measured by enzymatic methods and the genomic DNA was isolated from peripheral blood by DNA isolation kit.Polymerase chain reaction and restricted fragments polymorphism were used to determine HL genotype.Results:After adjusting age and BMI,the influence of HL genotype on profiles of HDL-C levels had staticstical significance(P<0.05)with values in the order of T/T+T/C>C/C.This effect appears more evident in male than in female(P<0.01 and P<0.05).Conclusions:HL-514C/T gene variants affect blood lipids and there exists gender difference,however the difference is not significant among the HL genotypes. |
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| Keywords: | hyperlipoproteinemia hepatic lipase genes, regulator variation |
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