Adverse reactions to immunotherapy are associated with different patterns of sensitization to grass allergens |
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| Authors: | J. Sastre F. Rodríguez P. Campo E. Laffond A. Marín M. D. Alonso |
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| Affiliation: | 1. Allergy, Fundación Jimenez Díaz, Madrid, Spain;2. Allergy, Hospital Marqués de Valdecilla, Santander, Spain;3. Allergy Service, Hospital Carlos Haya, Málaga, Spain;4. Allergy, Hospital Universitario de Salamanca, Salamanca, Spain;5. Medical Department, ALK‐Abello, Madrid, Spain;6. Unidad de Alergia, Fundación de Alcorcón, Alcorcón, Spain |
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| Abstract: | The aim of the study was to investigate whether adverse drug reactions (ADRs) during immunotherapy with a grass extract (AVANZ® Phleum, ALK‐Abelló) are related to the different patterns of sensitization of patients to grass allergens. A total of 192 patients with rhinitis and/or asthma sensitized to grass pollen received a 4‐week updosing with five injections. ADRs were evaluated following EAACI guidelines. A total of 432 ADRs in 133 (69%) patients were recorded, 64% local and 31% systemic. There was a significant association between the number of grass allergens that sensitized the patients and the total number of ADRs (P = 0.004) occurred locally (P = 0.003) and systemically (P = 0.01). Sensitization to Phl p1 + Phl p5 or Phl p1 + Phl p5 + Phl p12 was significantly associated with a higher frequency of local or systemic reactions (P = 0.001, both). Different patterns of sensitization to grass allergens may potentially be considered a risk marker to the development of ADRs to immunotherapy. |
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| Keywords: | grass allergens immunotherapy molecular diagnosis safety |
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