| Percutaneous Absorption and Metabolism of Ketoprofen Isopropyl Ester via Excised Nude Mouse‘s and Monkey’s Skin |
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| 引用本文： | ZHUQuan-gang HUJin-hong. Percutaneous Absorption and Metabolism of Ketoprofen Isopropyl Ester via Excised Nude Mouse‘s and Monkey’s Skin[J]. 中国药学, 2003, 12(1): 49-53 |
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| 作者姓名： | ZHUQuan-gang HUJin-hong |
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| 作者单位： | DepartmentofPharmacy,ChanghaiHospital,Shanghai200433,China |
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| 摘 要： | Aim:To study percutaneous absorption and metabolism of ketoprofen isopropyl ester (KPE)via excised nude mouse‘s and monkey‘s skin.Methods:Excised skin was prepared by surgical excision and enzyme digestion.Sideby-side diffusion cells were used for in vitro permeation studies.The concentrations of KPE and its metabolite in samples were assayed by HPLC.Results:All KPE penetration through whole thickness skin and stripped skin was metabolized to ketoprofen(KP).the concentration of which in the reciiver solution increased linearly with time.As to the nude mouse skin.the steady-state flux of KP through whole thickness skin was 2.5 times that of KPE through the whloe thickness skin,but the KP and KPE remaining in the whole thickness skin after the finishing of KPE penetration was 22.2 times in compered with the KP remaining in the whole thickness skin after the finshing of KP penetration.The rate of formation of the steady state KP from KPE throught dermis was significantly lower than that of KPE through the whole thickness skin.In he monkey skin,the rate of formation of the steady-state KP from KPE through the whole thickness skin was 0.7 times that from KPE through stripped skin.The KP and KPE remaining in the whole thickness skin after the finishing of KPE penetration was 2.0 time that in the stripped skin after the finishing of KPE penetration.The rate of fornation of the steady-state KP from KPE through dermis was lower than that from KPE through the whole thickness skin and the stripped skin.the KP remaining in dermis after the finsihing of KPE penetration was also significantly lower than the KP remaining in the whole thickness skin and the stripped skin after the finishing of KPE penetration.Conclusion:KP esters are of benefit to imporove the local action of KP.and skin esterase metabolism mainly develops in the epidermis.
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| 关 键 词： | 酮洛芬异丙酯 经皮吸收 表皮层 酯酶代谢 |
Percutaneous Absorption and Metabolism of Ketoprofen Isopropyl Ester via Excised Nude Mouse's and Monkey's Skin |
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| ZHU Quan-gang,HU Jin-hong. Percutaneous Absorption and Metabolism of Ketoprofen Isopropyl Ester via Excised Nude Mouse's and Monkey's Skin[J]. Journal of Chinese Pharmaceutical Sciences, 2003, 12(1): 49-53 |
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| Authors: | ZHU Quan-gang HU Jin-hong |
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| Abstract: | |
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| Keywords: | ketoprofen ketoprofen ketoprofen isopropyl ester ketoprofen isopropyl ester skin permeation skin permeation skin metabolism skin metabolism |
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