| 原发性开角型青光眼视神经损伤不同阶段血清细胞因子水平分析 |
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| 引用本文： | 王静,梁亮,莫纯坚. 原发性开角型青光眼视神经损伤不同阶段血清细胞因子水平分析[J]. 眼科新进展, 2015, 0(11): 1071-1072. DOI: 10.13389/j.cnki.rao.2015.0293 |
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| 作者姓名： | 王静 梁亮 莫纯坚 |
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| 作者单位： | 443000 湖北省宜昌市，三峡大学第一临床医学院，湖北省宜昌市中心人民医院眼科 |
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| 摘 要： | 目的 探讨不同视神经损伤阶段的原发性开角型青光眼（ｐｒｉｍａｒｙｏｐｅｎａｎｇｌｅｇｌａｕｃｏｍａ，ＰＯＡＧ）患者的血清细胞因子水平差异及临床价值。方法 选取２０１２年８月至２０１４年８月我院收治并确诊的ＰＯＡＧ患者６５例设为观察组，根据视神经损伤程度分为轻度损伤组（Ａ组）、中度损伤组（Ｂ组）及重度损伤组（Ｃ组），另纳入３０例白内障患者作为对照组，对观察组与对照组患者的白细胞介素-２（ｉｎｔｅｒｌｅｕｋｉｎ-２，ＩＬ-２）、ＩＬ-４、ＩＬ-６及ＩＬ-１２等血清细胞因子水平进行检测并比较。结果 观察组ＩＬ-２、ＩＬ-４、ＩＬ-６及ＩＬ-１２的水平分别为（９０．５１±４０．６１）ｐｇ·ｍＬ－１、（２４１．５４±７８．０２）ｐｇ·ｍＬ－１、（３４．８４±２９．３８）ｐｇ·ｍＬ－１、（９４．９１±５３．８９）ｐｇ·ｍＬ－１，对照组分别为（８９．９２±３８．０１）ｐｇ·ｍＬ－１、（１８５．０１±８４．０７）ｐｇ·ｍＬ－１、（６２．０１±２８．０５）ｐｇ·ｍＬ－１、（１３０．０１±８１．５８）ｐｇ·ｍＬ－１，观察组ＩＬ-６、ＩＬ-１２水平显著低于对照组，而ＩＬ-４水平显著高于对照组，差异均有统计学意义（均为Ｐ＜０．０５），但两组间ＩＬ-２差异无统计学意义（Ｐ＞０．０５）。Ａ组ＩＬ-１２水平显著高于Ｃ组（Ｐ＜０．０５），而Ａ、Ｂ、Ｃ三组ＩＬ-２、ＩＬ-４、ＩＬ-６等水平对比，差异均无统计学意义（均为Ｐ＞０．０５）。结论 ＩＬ-１２水平在不同视神经损伤阶段的ＰＯＡＧ患者存在较大差异，与ＩＬ-６可能共同起到对视网膜神经节细胞的保护作用，而ＩＬ-４则可损伤视网膜神经节细胞，提示检测血清细胞因子水平可反映视神经损伤的进程。
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| 关 键 词： | 原发性开角型青光眼 细胞因子 视神经损伤 |
Serum levels of cytokines at different stages of optic nerve injury in primary open-angle glaucoma |
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| WANG Jing,LIANG Liang,MO Chun-Jian. Serum levels of cytokines at different stages of optic nerve injury in primary open-angle glaucoma[J]. Recent Advances in Ophthalmology, 2015, 0(11): 1071-1072. DOI: 10.13389/j.cnki.rao.2015.0293 |
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| Authors: | WANG Jing LIANG Liang MO Chun-Jian |
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| Affiliation: | Department of Ophthalmology, Central People ’ s Hospital of Yichang , the First Clinical College of Three Corges University, Yichang 443000 . Hubei Province . China |
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| Abstract: | Objective To explore the serum cytokines level difference and clinical value at different stages of optic nerve injury in primary open-angle glaucoma patients. Methods Sixty-five patients with primary open-angle glaucoma in our hospital from August 2012 to August 2014 were chosen and set as observation group , according to the optic nerve damage degree the patients were divided into nuld injury group ( group A) .moderate injury group ( group B) and severe damage group ( group C) , and another 30 patients with cataract were set as control group , the serum levels of cytokines , such as interleukin-2 ( IL-2 ) . IL-4 . IL-6 . IL-12 , were tested and compared in the observation group and control group. Results The serum levels of IL-2 .IL-4 .IL-6 and IL-12 in the observation group were ( 90. 51 + 40. 61) pg . mL -1 , ( 241. 54 + 78. 02 ) pg . mL-’, ( 34. 84 + 29. 38) pg . mL ’l , ( 94. 91 + 53. 89) pg . mL -l , respectively , which in the control group were( 89. 92 + 38. 01) pg . mL -1 , ( 185. 01 + 84. 07) pg . mL ’l , ( 62. 01 + 28. 05 ) pg . mL -1 , ( 130. 01 + 81. 58) pg . mL -l , respectively , the level of IL-6 and IL-12 in the observation group were obviously lower than those in the control group ,but the level of IL-4 was higher( all P < 0. 05 ) , but there was no statistical difference in IL-12 between two groups(P > 0. 05 ) . The level of IL-12 in group A was obviously higher than group C (P < 0. 05 ) .but there was no statistical difference in IL-2 .IL-4 .IL-6 among group A, B and C ( all P > 0. 05 ) . Conclusion IL-12 level at different phases of optic nerve injury in patients with primary open-angle glaucoma is greatly different.it and IL-6 play a role in protecting retinal ganglion cells ,while IL-4 can damage the retinal ganglion cells , which suggest that detection of serum cytokine levels can reflect the process of optic nerve injury. |
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| Keywords: | primary open-angle glaucoma cytokines optic nerve injury |
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