| IL-2、IL-6及TNF-α在结外NK/T细胞淋巴瘤鼻型患者血清中的表达及临床意义 |
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| 引用本文： | 王媛媛,李兆明,张旭东,等. IL-2、IL-6及TNF-α在结外NK/T细胞淋巴瘤鼻型患者血清中的表达及临床意义[J]. 中国癌症杂志, 2015, 25(5): 377-381. DOI: 10.3969/j.issn.1007-3969.2015.05.010 |
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| 作者姓名： | 王媛媛 李兆明 张旭东 等 |
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| 作者单位： | 郑州大学第一附属医院淋巴瘤诊疗中心，河南 郑州 450052 |
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| 基金项目： | 国家自然科学基金(81402380)。 |
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| 摘 要： | 背景与目的：结外NK/T细胞淋巴瘤鼻型(extranodal NK/T-cell lymphoma，nasal type，ENKTL)属于非霍奇金淋巴瘤(non-Hodgkin's lymphoma，NHL)的一种少见类型，在亚洲国家发病率较欧美国家强。该病侵袭性强，发病机制至今仍尚未明确，但其与EB病毒(epstein-barr virus，EBV)感染密切相关。到目前为止ENKTL尚无标准治疗指南，其治疗效果不佳，患者预后极差，因此，探索ENKTL的发病机制势在必行。本研究探讨ENKTL患者血清中白细胞介素-2(interleukin，IL-2)、白细胞介素-6(interleukin-6，IL-6)和肿瘤坏死因子α(tumor necrosis factor-α，TNF-α)表达水平及其临床意义。方法：通过Luminex液相芯片技术检测67例ENKTL患者及26名正常人血清中的IL-2、IL-6和TNF-α的表达水平。结果：ENKTL患者血清中IL-2、IL-6和TNF-α的表达水平分别为(564.1±387.6)、(293.3±191.6)和(181.3±91.8)pg/mL；正常人血清中的IL-2、IL-6和TNF-α的表达水平分别为(1 097.0±365.7)、(417.5±289.6)和(291.3±89.4)pg/mL。和正常人相比，ENKTL患者血清中IL-2、IL-6和TNF-α的表达水平明显降低，差异有统计学意义(P<0.05)。进一步研究表明，经化疗达到完全缓解(complete response，CR)的5例ENKTL患者血清中TNF-α水平明显高于初治患者，分别为(162.7±10.3)和(125.2±7.3)pg/mL，差异有统计学意义(P<0.05)。结论：IL-2、IL-6和TNF-α在ENKTL患者血清中的表达水平降低，并且TNF-α的表达水平与化疗疗效密切相关。
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| 关 键 词： | 结外NK/T细胞淋巴瘤鼻型白细胞介素-2 白细胞介素-6 肿瘤坏死因子&alpha 炎性反应 |
The expressions of IL-2, IL-6 and TNF-α in the serum of extranodal NK/T-cell lymphoma (ENKTL) patients and their clinical significances |
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| WANG Yuanyuan,LI Zhaoming,ZHANG Xudong,et al. The expressions of IL-2, IL-6 and TNF-α in the serum of extranodal NK/T-cell lymphoma (ENKTL) patients and their clinical significances[J]. China Oncology, 2015, 25(5): 377-381. DOI: 10.3969/j.issn.1007-3969.2015.05.010 |
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| Authors: | WANG Yuanyuan LI Zhaoming ZHANG Xudong et al |
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| Affiliation: | Lymphoma Diagnosis and Treatment Center, First Affiliated Hospital, Zhengzhou University, Zhengzhou Henan 450052, China |
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| Abstract: | Background and purpose: Extranodal NK/T-cell lymphoma, nasal type (ENKTL) belongs to a rare type of non-Hodgkin's lymphoma (NHL). Its incidence rate in Asian country is higher than that in Western country. This disease is highly invasive, the pathogenesis of it is still unclear. Resent research shows that epstein-barr virus (EBV) is closely related to the occurrence of it. There is still no standard treatment guidelines of ENKTL, and the prognosis is very bad. Therefore, it is imperative to explore the pathogenesis of ENKTL. This study aimed to investigate the expressions of interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the serum of ENKTL patients and their clinical significances. Methods: Luminex liquid chip technology was used to detect the expression levels of IL-2, IL-6 and TNF-α in the serum of 67 ENKTL patients and 26 normal persons. Results: The expression levels of IL-2, IL-6 and TNF-α in the serum of 67 ENKTL patients were (564.1±387.6), (293.3±191.6) and (181.3±91.8)pg/mL, while in the normal persons were (1 097.0±365.7), (417.5±289.6) and (291.3±89.4)pg/mL, respectively. Compared with normal persons, the expression levels of IL-2, IL-6 and TNF-α in ENKTL patients were significantly lower (P<0.05). Further study showed that the expression level of TNF-α in 5 complete remission ENKTLpatients [(162.7±10.3)pg/mL] was significantly higher than that in initial treatment patients [(125.2±7.3)pg/mL, P<0.05]. Conclusion: The expressions of IL-2, IL-6 and TNF-α are reduced in the serum of ENKTL patients, and the serum expression level of TNF-α is closely related to the effect of chemotherapy. |
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| Keywords: | Extranodal NK/T-cell lymphoma nasal type Interleukin-2 Interleukin-6 Tumor necrosis factor-α Inflammation |
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