| miRNA 与胆道闭锁肝纤维化 |
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| 引用本文： | 卫园园,詹江华. miRNA 与胆道闭锁肝纤维化[J]. 天津医药, 2015, 43(11): 1334-1338. DOI: 10.11958/j.issn.0253-9896.2015.11.030 |
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| 作者姓名： | 卫园园 詹江华 |
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| 作者单位： | 1天津医科大学研究生院 （邮编300070）； 2天津市儿童医院外科 |
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| 基金项目： | 天津市卫生行业重点攻关项目(14KG129) |
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| 摘 要： | 胆道闭锁(BA)是婴儿期引起梗阻性黄疸的主要病因之一， 以肝内外胆管进行性炎症和纤维性梗阻为主要特征， 导致胆汁淤积和肝纤维化及肝硬化。肝纤维化中最重要的是肝星状细胞(HSC)的活化， 这一过程受到多种机制的调节， 其中 miRNA 家族成员可通过调控靶基因的表达， 进而作用于多种信号通路促进 HSC 的活化， 在细胞外基质(ECM)的合成和降解中发挥调节作用。大量文献表明 PI3K/Akt 信号通路与肝纤维化的发生、 发展密切相关， 参与了活化 HSC 增殖、 凋亡的调控， miRNA 通过各种靶基因激活 PI3K/Akt 信号通路， 进而激活 HSC， 促进肝纤维化的发展。本文就胆道闭锁肝纤维化相关的 miRNA综述如下。
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| 收稿时间： | 2015-03-26 |
| 修稿时间： | 2015-06-16 |
MicroRNA and hepatic fibrosis of biliary atresia |
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| WEI Yuanyuan,ZHAN Jianghua. MicroRNA and hepatic fibrosis of biliary atresia[J]. Tianjin Medical Journal, 2015, 43(11): 1334-1338. DOI: 10.11958/j.issn.0253-9896.2015.11.030 |
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| Authors: | WEI Yuanyuan ZHAN Jianghua |
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| Affiliation: | 1 Graduate School of Tianjin Medical University, Tianjin 300070, China;2 Department of Surgery, Tianjin Children’ s Hospital |
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| Abstract: | Biliary atresia (BA), an inflammatory sclerosing cholangiopathy, is the leading cause of cholestasis in infants. Pathologic features of BA include progressive inflammation and intrahepatic and extrahepatic bile duct fibrosis. BA is characterized by rapid liver fibrosis. The activation of hepatic stellate cell (HSC) is most important in liver fibrosis. Many mechanisms are involved in this process. miRNA can promote the activation of HSC through a variety of signaling pathways by regulating the expression of target gene, then playing a regulatory role in the synthesis and degradation of extracellular matrix (ECM). A lot of literatures show that PI3K/Akt is closely related to the occurrence and development of hepatic fibrosis. PI3K/Akt signaling pathway is involved in the activation of HSC proliferation and apoptosis. MiRNA activates PI3K/Akt signaling pathway through various target genes, and then activates HSC to promote the development of liver fibrosis. In this paper, the miRNA related to biliary atresia of liver fibrosis is summarized. |
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| Keywords: | microRNAs biliary atresia liver cirrhosis astrocytes review |
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