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头孢西丁钠与注射用炎琥宁配伍稳定性考察
引用本文:朱雪松,李鹏,郑芳,陈富超. 头孢西丁钠与注射用炎琥宁配伍稳定性考察[J]. 中国药师, 2010, 13(4): 539-540
作者姓名:朱雪松  李鹏  郑芳  陈富超
作者单位:郧阳医学院附属东风医院药剂部,湖北十堰,442008
摘    要:目的:考察注射用头孢西丁钠与注射用炎琥宁在0.9%氯化钠注射液中的配伍稳定性。方法:在20℃下采用RP.HPLC法测定注射用头孢西丁钠与注射用炎琥宁在0.9%氯化钠注射液中配伍后8h内不同时间点的含量。并观察和检测配伍液的外观及pH变化。结果:在室温下配伍液8h内的含量、pH及外观均无明显变化。结论:注射用头孢西丁钠与注射用炎琥宁20℃在0.9%氯化钠注射液中可在配伍后8h内使用。

关 键 词:高效液相色谱法  头孢西丁钠  注射用炎琥宁  配伍  稳定性

Compatible Stability of Cefoxitin Sodium for Injection and Potassium Sodium Dehydroandrographolide Succinate for Injection
Zhu Xuesong,Li Peng,Zheng Fang,Chen Fuchao. Compatible Stability of Cefoxitin Sodium for Injection and Potassium Sodium Dehydroandrographolide Succinate for Injection[J]. China Pharmacist, 2010, 13(4): 539-540
Authors:Zhu Xuesong  Li Peng  Zheng Fang  Chen Fuchao
Affiliation:( Department of Pharmacy, Affiliated Dongfeng Hospital, Yunyang Medical College, Hubei Shiyan 442008 ,China)
Abstract:Objective: To evaluate the compatible stability of the mixture of cefoxitin sodium for injection with potassium sodium dehydroandregrapholide succinate for injection in 0. 9% sodium chloride injection. Method: HPLC method was designed to study the change of content after combination of cefoxitin sodium for injection with potassium sodium dehydroandrographolide succinate in 0. 9% sodium chloride injection under the room temperature (20 ~C ) within 8 hours, and the appearance of the solution was observed and its pH value was determined. Result: No significant differences were found in the content, colour and pH value for the mixed solution de- termined at different time within 8 hours after mixing at room temperature. Concbmion: Cefoxitin sodium for injection and potassium so- dium dehydroandrographolide succinate can be mixed in 0. 9% sodium chloride injection,and used within 8 hours.
Keywords:HPLC  Cefoxitin sodium  Potassium sodium dehydroandregrapholide succinate for injection  Compatibility  Stability
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