Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy |
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| Authors: | C. M. Finlay A. M. Stefanska M. M. Coleman H. Jahns J. P. Cassidy R. M. McLoughlin K. H. G. Mills |
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| Affiliation: | 1. Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland;2. School of Veterinary Medicine, Veterinary Science Centre, University College Dublin, Dublin 4, Ireland;3. Host‐Pathogen Interactions Group School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin 2, Ireland |
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| Abstract: | There is evidence from epidemiology studies of a negative association between infection with helminth parasites and the development of allergy and asthma. Here, we demonstrate that the excretory/secretory products of the helminth Fasciola hepatica (FHES) protected mice against ovalbumin (OVA)‐induced allergic asthma when administered at time of allergen sensitization. FHES reduced the accumulation of mucus, eosinophils and lymphocytes into the airways of allergen‐challenged mice. Furthermore, FHES treatment suppressed Th2 responses in the airways. Interestingly, systemic administration of FHES at allergen challenge had no effect on airway inflammation, demonstrating that alum‐induced Th2 response is set following initial allergen sensitization. Our findings highlight the immunomodulatory potential of molecules secreted by F. hepatica. |
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| Keywords: | allergy/atopy asthma
Fasciola hepatica
immune modulation |
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