| 过氧化苯甲酰对小鼠肝脏组织损伤作用 |
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| 引用本文： | 贾晓静, 刘萍, 李玉彩, 曹胜楠, 张贝贝. 过氧化苯甲酰对小鼠肝脏组织损伤作用[J]. 中国公共卫生, 2011, 27(2): 229-230. DOI: 10.11847/zgggws2011-27-02-51 |
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| 作者姓名： | 贾晓静 刘萍 李玉彩 曹胜楠 张贝贝 |
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| 作者单位： | 1.山东大学公共卫生学院卫生检验研究所, 山东 济南 250012 |
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| 摘 要： | 目的 探讨面粉增白剂过氧化苯甲酰(benzoyl peroxide,BPO)对小鼠肝脏组织的损伤作用。方法 64只昆明种小鼠随机分为对照组和低、中、高剂量BPO组,分别灌胃给予BPO 50,100和200 mg/kg,每组16只,雌雄各半;灌胃6周后,测定各组肝脏组织中谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量及三磷酸腺苷(ATP)酶活力。结果 高、中剂量BPO组SOD活力分别为(40.15±7.13),(46.01±6.69)U/(mg·prot),与对照组(53.15±6.55)U/(mg·prot)比较,差异有统计学意义(P<0.05);高剂量BPO组与对照组MDA含量分别为(1.93±0.37)和(1.57±0.33)nmol/(mg·prot),差异有统计学意义(P<0.05);高剂量BPO组Mg2+-ATP、Ca2+-ATP酶活力分别为(1.58±0.11)和(1.48±0.09)μmol Pi/(mg·prot),与对照组比较明显降低,差异有统计学意义(P<0.05);各剂量BPO组GSH-Px活力与对照组比较差异无统计学意义(P>0.05)。结论 BPO在一定程度上可降低小鼠肝脏抗氧化及Ca2+、Mg2+-ATP酶活力。
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| 关 键 词： | 过氧化苯甲酰 谷胱甘肽过氧化物酶 超氧化物歧化酶 丙二醛 ATP酶 |
| 收稿时间： | 2010-06-11 |
Effect of benzoyl peroxide on liver tissue of mice |
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| JIA Xiao-jing, LIU Ping, LI Yu-cai, . Effect of benzoyl peroxide on liver tissue of mice[J]. Chinese Journal of Public Health, 2011, 27(2): 229-230. DOI: 10.11847/zgggws2011-27-02-51 |
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| Authors: | JIA Xiao-jing LIU Ping LI Yu-cai |
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| Affiliation: | 1.Department of Chemistry and Microbacteria Detection, College of Public Health, Shandong University Ji'nan 250012, China |
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| Abstract: | Objective To investigate the effect of benzoyl peroxide(BPO) as a flour bleeding agent on liver tissue of mice.Methods Sixty-four Kunming mice were randomly divided into four groups:control group,low,moderate,and high dose BPO groups.The mice in exposure groups were administered with 50,100,and 200 mg/kg BPO by gavage for 6 weeks.Then the content of malondia ldehyde (MDA) and activities of glutathione peroxidase (GSH-Px),superoxide dismutase(SOD),Na+K+-ATPase,Mg2+-ATPase,and Ca2+-ATPase in the liver were determined.Results The activity of SOD in high and moderate BPO groups were 40.15±7.13,46.01±6.69 U/mg·prot,respectively,with significant differences compared to that of the control group(53.15±6.55 U/mg·prot,P < 0.05).The difference in the content of MDA was statistically significant between high BPO and control group (1.93±0.37 vs 1.57±0.33 nmol/mg·prot,P< 0.05).Compared with the control group,the activities of Mg2+-ATPase and Ca2+-ATPase in high BPO group decreased statistically (1.58±0.11 vs 1.48±0.09 molPi/mg·prot/huor,P < 0.05).There was no significant difference between BPO groups and control group in the activity of GSH-Px (P > 0.05).Conclusion BPO has certain harmeffect on antioxidant status and the activity of Ca2+ Mg2+-ATPase of liver tissue in mice. |
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| Keywords: | benzoyl peroxide (BPO) glutathione peroxidase (GSH-Px) superoxide dismutase (SOD) malondialdehyde (MDA) ATPases |
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