Family study of the major histocompatibility complex in HLA DR3 negative patients with systemic lupus erythematosus |
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| Authors: | J. R. Batchelor A. H. L. Fielder M. J. Walport J. David D. K. Lord N. Davey I. A. Dodi P. Malasit W. Wanachiwanawin R. Bernstein C. Mackworth-Young D. Isenberg |
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| Affiliation: | Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK. |
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| Abstract: | Susceptibility to systemic lupus erythematosus (SLE) is known to be governed by genes in the HLA region of the 6th chromosome. From previous studies it has not been possible to distinguish between the effects of null genes for the complement component C4 and HLA-DR3, because of the marked linkage disequilibrium between DR3 and a null allele of C4A (C4A QO) in caucasoid populations. We report here an immunogenetic study of 44 cases of SLE, selected because they were DR3 negative. Eighteen of the 30 Caucasoid cases (60%) had extended HLA haplotypes with a C4 null allele, compared with 22 of 60 (37%) of a control panel of 60 DR3 negative normal Caucasoid subjects. This difference is significant (chi 2 = 4.41; 0.05 greater than P greater than 0.01). Of 14 non-caucasoid patients analysed, 10 had a C4 null allele. It is concluded that the null alleles of the C4 A and B genes are themselves directly responsible for conferring susceptibility to SLE. |
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