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| 热休克蛋白在器官移植中的作用研究现状 | |
| 引用本文： | 程学超, 宋永祥, 孟辉. 热休克蛋白在器官移植中的作用研究现状[J]. 器官移植, 2023, 14(3): 455-460. doi: 10.3969/j.issn.1674-7445.2023.03.019 |
| 作者姓名： | 程学超 宋永祥 孟辉 |
| 作者单位： | 519100 广东珠海，遵义医科大学第五附属（珠海）医院心胸外科（程学超、孟辉）；遵义医科大学附属医院胸外科（宋永祥） |
| 基金项目： | 甘肃省自然科学基金（1606RJZA184）； |
| 摘 要： |  器官移植是多种终末期疾病有效的治疗方案，近年来，器官移植领域发展迅速，并得到广泛认可和应用，但供者利用率低和术后并发症高仍是亟需解决的问题。热休克蛋白（HSP）是一类由热休克或其他应激源诱导表达的蛋白质家族，应激刺激时HSP通过发挥抗炎、抗氧化、抗凋亡作用来减少应激带来的损伤，HSP还参与促进免疫反应、抗排斥反应等过程。器官移植手术作为应激刺激，诱导HSP在移植过程中通过多途径发挥作用，从而减轻移植物组织损伤、提高供者利用率、延长移植受者术后生存时间。本文就HSP在肺移植、心脏移植、肝移植、肾移植中的作用研究现状进行综述，旨在为器官移植供者保护及术后并发症的治疗提供参考。 |
| 关 键 词： | 热休克蛋白 器官移植 肺移植 心脏移植 肝移植 肾移植 器官保护 缺血-再灌注损伤 |
| 收稿时间： | 2022-12-29 |
Research status on the role of heat shock protein in organ transplantation |
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| Cheng Xuechao, Song Yongxiang, Meng Hui. Research status on the role of heat shock protein in organ transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 455-460. doi: 10.3969/j.issn.1674-7445.2023.03.019 | |
| Authors: | Cheng Xuechao Song Yongxiang Meng Hui |
| Affiliation: | Department of Cardiothoracic Surgery, the Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai 519100, China |
| Abstract: | Organ transplantation is an effective treatment for multiple end-stage diseases. In recent years, rapid progress has been made in the field of organ transplantation, which has been widely accepted and applied in clinical practice. However, low utilization rate of donors and high postoperative complications remain to be urgently resolved. Heat shock protein (HSP) is a category of protein family induced by heat shock or other stressors. Upon stress stimulation, HSP plays an anti-inflammation, anti-oxidation and anti-apoptosis role in mitigating the stress-induced damage. HSP is also involved in the processes of promoting immune response and anti-rejection, etc. Organ transplantation, as a stress stimulus, could induce HSP to function in the process of organ transplantation through many patterns, thereby alleviating the allograft damage, improving the utilization rate of donors and prolonging the postoperative survival of recipients. In this article, research status on the role of HSP in lung transplantation, heart transplantation, liver transplantation and kidney transplantation were reviewed, aiming to provide reference for donor protection of organ transplantation and treatment of postoperative complications. |
| Keywords: | Heat shock protein Organ transplantation Lung transplantation Heart transplantation Liver transplantation Kidney transplantation Organ protection Ischemia-reperfusion injury |
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