Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa |
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| Authors: | Thorner Anna R Vogels Ronald Kaspers Jorn Weverling Gerrit J Holterman Lennart Lemckert Angelique A C Dilraj Athmanundh McNally Lisa M Jeena Prakash M Jepsen Soren Abbink Peter Nanda Anjali Swanson Patricia E Bates Andrew T O'Brien Kara L Havenga Menzo J E Goudsmit Jaap Barouch Dan H |
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| Affiliation: | Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Research East, Room 213, 330 Brookline Avenue, Boston, MA 02215, USA. |
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| Abstract: | We assessed neutralizing antibody titers to adenovirus serotype 5 (Ad5) and six rare adenovirus serotypes, serotypes 11, 35, 50, 26, 48, and 49, in pediatric populations in sub-Saharan Africa. We observed a clear age dependence of Ad5-specific neutralizing antibody titers. These data will help to guide the development of Ad vector-based vaccines for human immunodeficiency virus type 1 and other pathogens. |
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