Conformation of cyclolinopeptide a observed by circular dichroism |
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| Authors: | Naider F Benedetti E Goodman M |
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| Affiliation: | Polytechnic Institute of Brooklyn, Brooklyn, New York 11201. |
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| Abstract: | A stereochemical investigation, by circular dichroism, of a synthetic nonapeptide (cyclolinopeptide A) in several organic and organic-sulfuric acid solvents is presented. From this examination, and results found for a conformationally rigid model compound, 1,7,7-trimethyl-3-azabicyclo [2.2.1] heptan-2-one(camphorolactam), it is concluded that cyclolinopeptide A may exist in several conformations in solution. None of these conformations is believed to be stabilized by intramolecular hydrogen bonds. Some details on an x-ray analysis of the cyclic nonapeptide are also presented. |
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