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| 阿奇霉素分散片崩解剂优选研究 | |
| 引用本文： | 宗永斌,万元松,金春,秦勇. 阿奇霉素分散片崩解剂优选研究[J]. 医药导报, 2012, 31(1): 72-74. DOI: 10.3870/yydb.2012.01.028 |
| 作者姓名： | 宗永斌 万元松 金春 秦勇 |
| 作者单位： | 1. 江苏神龙药业有限公司,盐城224260;武汉大学药学院,430071 2. 江苏弘惠医药有限公司,南京,210008 3. 江苏神龙药业有限公司,盐城224260;江苏弘惠医药有限公司,南京210008 |
| 摘 要： | 目的 为提高阿奇霉素分散片的质量,研究崩解剂对其分散性的影响. 方法选择羧甲基淀粉钠、交联聚乙烯吡咯烷酮及其他适宜辅料,制备处方. 结果 选择羧甲基淀粉钠作崩解剂及恰当的制剂工艺可以明显提高阿奇霉素分散片的质量. 结论 该处方合理稳定,溶出度和分散均匀性好. |
| 关 键 词： | 阿奇霉素分散片 羧甲基淀粉钠 交联聚乙烯吡咯烷酮 崩解剂 分散性 |
| 收稿时间： | 2011-05-09 |
Optimization of Screening Disintegrants for Azithromycin Dispersible Tablets |
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| ZONG Yong-bing,WAN Yuan-song,JIN Chun,QIN Yong. Optimization of Screening Disintegrants for Azithromycin Dispersible Tablets[J]. Herald of Medicine, 2012, 31(1): 72-74. DOI: 10.3870/yydb.2012.01.028 | |
| Authors: | ZONG Yong-bing WAN Yuan-song JIN Chun QIN Yong |
| Affiliation: | 1,3(1.Jiangsu Shenlong Pharmaceutical Co.,Ltd.,Yancheng 224260,China;2.School of Pharmacy,Wuhan University,Wuhan 430071,China;3.Jiangsu Honghui Medical Co.,Ltd.,Nanjing 210008,China) |
| Abstract: | Objective To study impact of disintegrants on the uniformity of tablets’ disperse for improving the quality of azithromycin dispersible tablets.Methods Sodium carboxymethyl starch,crosslinked polyvinylpyrrolidone and other suitable ingredients were used to prepare the tablets.Results The sodium carboxymethyl starch and proper preparation significantly enhanced the quality of azithromycin dispersible tablets.Conclusion The preparation is reasonable and stable,which is evenly dispersed and well dissolved. |
| Keywords: | Azithromycin dispersible tablets Sodium carboxymethyl starch Crosslinked polyvinylpyrrolidone Disintegrating agents Disperse property |
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