Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1‐integrin |
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| Authors: | Guillaume Martin‐Blondel Béatrice Pignolet Silvia Tietz Lidia Yshii Christina Gebauer Therese Perinat Isabelle Van Weddingen Claudia Blatti Roland Liblau |
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| Affiliation: | 1. Department of Infectious and Tropical Diseases, Toulouse University Hospital, Toulouse, France;2. INSERM U1043 ‐ CNRS UMR 5282, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France;3. Université Toulouse III, Toulouse, France;4. Department of Clinical Neurosciences, Toulouse University Hospital, Toulouse, France;5. Theodor Kocher Institute, University of Bern, Bern, Switzerland |
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| Abstract: | Although CD8 T cells are key players in neuroinflammation, little is known about their trafficking cues into the central nervous system (CNS). We used a murine model of CNS autoimmunity to define the molecules involved in cytotoxic CD8 T‐cell migration into the CNS. Using a panel of mAbs, we here show that the α4β1‐integrin is essential for CD8 T‐cell interaction with CNS endothelium. We also investigated which α4β1‐integrin ligands expressed by endothelial cells are implicated. The blockade of VCAM‐1 did not protect against autoimmune encephalomyelitis, and only partly decreased the CD8+ T‐cell infiltration into the CNS. In addition, inhibition of junctional adhesion molecule‐B expressed by CNS endothelial cells also decreases CD8 T‐cell infiltration. CD8 T cells may use additional and possibly unidentified adhesion molecules to gain access to the CNS. |
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| Keywords: | α 4β 1‐Integrin CD8 T cell Junctional adhesion molecule‐B Migration Neuroinflammation |
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