Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer |
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| Authors: | Stella Tommasi Deborah L Karm Xiwei Wu Yun Yen Gerd P Pfeifer |
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| Affiliation: | (1) Department of Cancer Biology, Beckman Research Institute of the City of Hope, 91010 Duarte, California, USA;(2) Division of Information Sciences, Beckman Research Institute of the City of Hope, 91010 Duarte, California, USA;(3) Department of Clinical and Molecular Pharmacology, Beckman Research Institute of the City of Hope, 91010 Duarte, California, USA |
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| Abstract: | Introduction Aberrant methylation of CpG islands is a hallmark of cancer and occurs at an early stage in breast tumorigenesis. However, its impact on tumor development is not fully determined, and its potential as a diagnostic biomarker remains to be validated. Methylation profiling of invasive breast carcinoma has been largely explored. Conversely, very little and sparse information is available on early-stage breast cancer. To gain insight into the epigenetic switches that may promote and/or contribute to the initial neoplastic events during breast carcinogenesis, we have analyzed the DNA methylation profile of ductal carcinoma in situ, a premalignant breast lesion with a great potential to progress toward invasive carcinoma. |
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